Rashad Al-Salahi1, Hanan A A Taie2, Ahmed H Bakheit3, Mohamed Marzouk4, Abdulrahman A Almehizia5, Rashed Herqash5, Hatem A Abuelizz5. 1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: ralsalahi@ksu.edu.sa. 2. Plant Biochemistry Department, Division of Agriculture and Biological Researches, National Research Centre, Giza, Egypt. 3. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, El-Neelain University, Khartoum, Sudan. 4. Chemistry of Natural Products Group, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, Egypt. 5. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abstract
BACKGROUND: Oxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the damage caused by free radicals. METHODS: The present study evaluated the antioxidant activities of 15 derivatives of 2-thioxobenzo[g]quinazoline using three different assays: 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, reducing power capability, and ferric reduction antioxidant power. RESULTS: Some benzoquinazolines had good activity and had the capacity to deplete DPPH and free radicals compared to a positive control butylated hydroxyl toluene (BHT). A docking study identified the possible interactions between binding models and the antioxidant activities of the target compounds. CONCLUSIONS: The active compounds can be used as templates for further development of more potent antioxidative agents.
BACKGROUND: Oxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the damage caused by free radicals. METHODS: The present study evaluated the antioxidant activities of 15 derivatives of 2-thioxobenzo[g]quinazoline using three different assays: 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, reducing power capability, and ferric reduction antioxidant power. RESULTS: Some benzoquinazolines had good activity and had the capacity to deplete DPPH and free radicals compared to a positive control butylated hydroxyl toluene (BHT). A docking study identified the possible interactions between binding models and the antioxidant activities of the target compounds. CONCLUSIONS: The active compounds can be used as templates for further development of more potent antioxidative agents.
Authors: Zafar Ali Shah; Adil A H Mujawah; Irfan Ullah; Abdur Rauf; Umer Rashid; Anees Ahmed Khalil; Syed Muhammad Mukarram Shah; Aini Pervaiz; Farzana Shaheen; Yahya S Al-Awthan; Muhammad Nasimullah Qureshi; Mohammed A Al-Duais; Omar Bahattab; Zainab M Almarhoon; Yahia N Mabkhot; Mohammad S Mubarak Journal: Oxid Med Cell Longev Date: 2022-01-20 Impact factor: 6.543
Authors: Eman M Fathalla; Mezna Saleh Altowyan; Jörg H Albering; Assem Barakat; Morsy A M Abu-Youssef; Saied M Soliman; Ahmed M A Badr Journal: Molecules Date: 2022-02-06 Impact factor: 4.411