Brian Zhaojie Chin1, Tao Ji2, Xiaodong Tang3, Rongli Yang3, Wei Guo3. 1. Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing, China; University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore. 2. Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing, China. Electronic address: jitaomd@163.com. 3. Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing, China.
Abstract
BACKGROUND: Primary malignancies involving the mobile spine often require total en bloc spondylectomy with complex mechanical reconstruction, which can be augmented with novel application of the 3-dimensional (3D)-printing technique. CASE DESCRIPTION: A 51-year-old man presented with a 12-month history of progressive thigh pain and lower limb motor function loss, 36 months after T12-L4 instrumentation and fusion for giant cell tumor (GCT) of the L2 vertebrae before referral. The patient subsequently underwent successful curative management of recurrent GCT through denosumab treatment, L1-L3 total en bloc spondylectomy (TES), and a novel lumbopelvic reconstruction method with a 3D-printed lumbar vertebrae and screw-rod system. CONCLUSIONS: To our knowledge, this is the first reported case of multilevel lumbar TES for GCT reconstructed using a 3D-printed vertebrae. Although TES-specifically in the lumbosacral spine-remains challenging due to its unique anatomy and increased risk of neurologic insult, it is an effective option for curative management of GCTs.
BACKGROUND:Primary malignancies involving the mobile spine often require total en bloc spondylectomy with complex mechanical reconstruction, which can be augmented with novel application of the 3-dimensional (3D)-printing technique. CASE DESCRIPTION: A 51-year-old man presented with a 12-month history of progressive thigh pain and lower limb motor function loss, 36 months after T12-L4 instrumentation and fusion for giant cell tumor (GCT) of the L2 vertebrae before referral. The patient subsequently underwent successful curative management of recurrent GCT through denosumab treatment, L1-L3 total en bloc spondylectomy (TES), and a novel lumbopelvic reconstruction method with a 3D-printed lumbar vertebrae and screw-rod system. CONCLUSIONS: To our knowledge, this is the first reported case of multilevel lumbar TES for GCT reconstructed using a 3D-printed vertebrae. Although TES-specifically in the lumbosacral spine-remains challenging due to its unique anatomy and increased risk of neurologic insult, it is an effective option for curative management of GCTs.
Authors: Roberta Costanzo; Gianluca Ferini; Lara Brunasso; Lapo Bonosi; Massimiliano Porzio; Umberto Emanuele Benigno; Sofia Musso; Rosa Maria Gerardi; Giuseppe Roberto Giammalva; Federica Paolini; Paolo Palmisciano; Giuseppe Emmanuele Umana; Carmelo Lucio Sturiale; Rina Di Bonaventura; Domenico Gerardo Iacopino; Rosario Maugeri Journal: Life (Basel) Date: 2022-03-28