Yujun Hu1, Tianzhu Lu1, Shao Hui Huang2, Shaojun Lin3,4, Yunbin Chen5, Yanhong Fang5, Han Zhou1, Yiping Chen1, Jingfeng Zong3, Yu Zhang3, Ying Chen5, Jianji Pan3,4, Youping Xiao5, Qiaojuan Guo3,4,6. 1. Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fuzhou, China. 2. Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada. 3. Department of Radiation Oncology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou, China. 4. Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, Fuzhou, Fujian, China. 5. Department of Radiology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou, China. 6. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
Abstract
BACKGROUND: To investigate the prognostic value of radiologic extra-nodal extension (rENE) in stage II nasopharyngeal carcinoma (NPC). METHODS: Stage II NPC patients with N1 category (n = 365) were enrolled and divided into three groups according to the situation of rENE: without rENE, suspected rENE, and confirmed rENE (grades: A, infiltration into surrounding fat; B, matted nodes; C, infiltration into adjacent structures). RESULTS: Only high-grade rENE (including matted nodes and infiltration into adjacent structures) could significantly influence the survival outcomes, patients with high-grade rENE had significantly poorer survival than those without, with the 7-year distant metastasis-free survival and overall survival demonstrated to be 78.5% vs 93.0% (P < .001) and 81.9% vs 89.9% (P = .05), respectively. High-grade rENE, as defined in our study, is a stable criterion, with high intra-rater and inter-rater consistency. CONCLUSION: High-grade rENE was an evaluable predictor that could help with the selection of stage II patients with high risk of distant metastasis.
BACKGROUND: To investigate the prognostic value of radiologic extra-nodal extension (rENE) in stage II nasopharyngeal carcinoma (NPC). METHODS: Stage II NPC patients with N1 category (n = 365) were enrolled and divided into three groups according to the situation of rENE: without rENE, suspected rENE, and confirmed rENE (grades: A, infiltration into surrounding fat; B, matted nodes; C, infiltration into adjacent structures). RESULTS: Only high-grade rENE (including matted nodes and infiltration into adjacent structures) could significantly influence the survival outcomes, patients with high-grade rENE had significantly poorer survival than those without, with the 7-year distant metastasis-free survival and overall survival demonstrated to be 78.5% vs 93.0% (P < .001) and 81.9% vs 89.9% (P = .05), respectively. High-grade rENE, as defined in our study, is a stable criterion, with high intra-rater and inter-rater consistency. CONCLUSION: High-grade rENE was an evaluable predictor that could help with the selection of stage II patients with high risk of distant metastasis.
Authors: Giancarlo Tirelli; Jasmina de Groodt; Egidio Sia; Manuel Gianvalerio Belgrano; Ferruccio Degrassi; Paolo Boscolo-Rizzo; Maria Assunta Cova; Alberto Vito Marcuzzo Journal: J Med Imaging (Bellingham) Date: 2021-02-01