Literature DB >> 31206681

SPTBN1 and cancer, which links?

Shuyi Chen1, Jiajia Li2, Ping Zhou1, Xiuling Zhi1.   

Abstract

SPTBN1 is a dynamic intracellular nonpleckstrin homology-domain protein, functioning as a transforming growth factor-β signal transducing adapter protein which is necessary to form Smad3/Smad4 complex. Recently SPTBN1 is considered to be associated with many kinds of cancers. SPTBN1 expression and function differ between different tumor states or types. This review summarizes the recent advances in the expression patterns of SPTBN1 in cancers, and in understanding the mechanisms by which SPTBN1 affects the occurrence, progression, and metastasis of cancer. Identifying SPTBN1 expression and function in cancers will contribute to the clinical diagnosis and treatment of cancer and the investigation of anticancer drugs.
© 2019 Wiley Periodicals, Inc.

Entities:  

Keywords:  DNA repair; SPTBN1; TGF-β signal pathway; Wnt signal pathway; cancer; epithelial-mesenchymal transition (EMT)

Year:  2019        PMID： 31206681     DOI： 10.1002/jcp.28975

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  6 in total

1.  Early and late stage MPN patients show distinct gene expression profiles in CD34+ cells.

Authors:  Julian Baumeister; Tiago Maié; Nicolas Chatain; Lin Gan; Barbora Weinbergerova; Marcelo A S de Toledo; Jörg Eschweiler; Angela Maurer; Jiri Mayer; Blanka Kubesova; Zdenek Racil; Andreas Schuppert; Ivan Costa; Steffen Koschmieder; Tim H Brümmendorf; Deniz Gezer
Journal:  Ann Hematol       Date:  2021-08-14       Impact factor: 4.030

2.  SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis.

Authors:  Xiaofen Zhou; Lizhi Lin; Yufeng Qi; Min Xu; Qiding Xu; Yinghao Wang; Jinmiao Qu
Journal:  Dis Markers       Date:  2022-08-03       Impact factor: 3.464

3.  Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas.

Authors:  Tsai-Der Chuang; Derek Quintanilla; Drake Boos; Omid Khorram
Journal:  Reprod Sci       Date:  2022-05-31       Impact factor: 2.924

4.  Transcriptomic signatures across human tissues identify functional rare genetic variation.

Authors:  Nicole M Ferraro; Benjamin J Strober; Pejman Mohammadi; Stephen B Montgomery; Alexis Battle; Jonah Einson; Nathan S Abell; Francois Aguet; Alvaro N Barbeira; Margot Brandt; Maja Bucan; Stephane E Castel; Joe R Davis; Emily Greenwald; Gaelen T Hess; Austin T Hilliard; Rachel L Kember; Bence Kotis; YoSon Park; Gina Peloso; Shweta Ramdas; Alexandra J Scott; Craig Smail; Emily K Tsang; Seyedeh M Zekavat; Marcello Ziosi; Kristin G Ardlie; Themistocles L Assimes; Michael C Bassik; Christopher D Brown; Adolfo Correa; Ira Hall; Hae Kyung Im; Xin Li; Pradeep Natarajan; Tuuli Lappalainen
Journal:  Science       Date:  2020-09-10       Impact factor: 63.714

5.  SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway.

Authors:  Mo Chen; Jia Zeng; Shuyi Chen; Jiajia Li; Huijie Wu; Xuhui Dong; Yuan Lei; Xiuling Zhi; Liangqing Yao
Journal:  Aging (Albany NY)       Date:  2020-06-08       Impact factor: 5.682

Review 6.  βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases.

Authors:  Panyu Yang; Yanyan Yang; Pin Sun; Yu Tian; Fang Gao; Chen Wang; Tingyu Zong; Min Li; Ying Zhang; Tao Yu; Zhirong Jiang
Journal:  Int J Biol Sci       Date:  2021-01-01       Impact factor: 6.580
  6 in total

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