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Literature DB >> 31206634

The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin?

Abstract

Translation of mRNA is a highly regulated process that is tightly coordinated with cotranslational protein maturation. Recently, mRNA modifications and tRNA modifications - the so called epitranscriptome - have added a new layer of regulation that is still poorly understood. Both types of modifications can affect codon-anticodon interactions, thereby affecting mRNA translation and protein synthesis in similar ways. Here, we describe an updated view on how the different types of modifications can be mapped, how they affect translation, how they trigger phenotypes and discuss how the combined action of mRNA and tRNA modifications coordinate translation in health and disease.

Keywords: RNA modification; RNA sequencing; disease; epitranscriptome; post-transcriptional modifications; ribosome; translation

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Year: 2019 PMID： 31206634 DOI： 10.1002/1873-3468.13491

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

14 in total

1. MODOMICS: An Operational Guide to the Use of the RNA Modification Pathways Database.

Authors: Pietro Boccaletto; Błażej Bagiński
Journal: Methods Mol Biol Date: 2021

Review 2. Proteomic and interactomic insights into the molecular basis of cell functional diversity.

Authors: Isabell Bludau; Ruedi Aebersold
Journal: Nat Rev Mol Cell Biol Date: 2020-03-31 Impact factor: 94.444

3. Dynamic changes in tRNA modifications and abundance during T cell activation.

Authors: Roni Rak; Michal Polonsky; Inbal Eizenberg-Magar; Yufeng Mo; Yuriko Sakaguchi; Orel Mizrahi; Aharon Nachshon; Shlomit Reich-Zeliger; Noam Stern-Ginossar; Orna Dahan; Tsutomu Suzuki; Nir Friedman; Yitzhak Pilpel
Journal: Proc Natl Acad Sci U S A Date: 2021-10-19 Impact factor: 11.205

Review 4. The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine.

Authors: Adele Alagia; Monika Gullerova
Journal: Front Cell Dev Biol Date: 2022-06-03

5. THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder.

Authors: Martin Broly; Bogdan V Polevoda; Kamel M Awayda; Ning Tong; Jenna Lentini; Thomas Besnard; Wallid Deb; Declan O'Rourke; Julia Baptista; Sian Ellard; Mohammed Almannai; Mais Hashem; Ferdous Abdulwahab; Hanan Shamseldin; Saeed Al-Tala; Fowzan S Alkuraya; Alberta Leon; Rosa L E van Loon; Alessandra Ferlini; Mariabeatrice Sanchini; Stefania Bigoni; Andrea Ciorba; Hans van Bokhoven; Zafar Iqbal; Almundher Al-Maawali; Fathiya Al-Murshedi; Anuradha Ganesh; Watfa Al-Mamari; Sze Chern Lim; Lynn S Pais; Natasha Brown; Saima Riazuddin; Stéphane Bézieau; Dragony Fu; Bertrand Isidor; Benjamin Cogné; Mitchell R O'Connell
Journal: Am J Hum Genet Date: 2022-02-22 Impact factor: 11.043

6. An intellectual disability-associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity.

Authors: Kejia Zhang; Jenna M Lentini; Christopher T Prevost; Mais O Hashem; Fowzan S Alkuraya; Dragony Fu
Journal: Hum Mutat Date: 2020-01-16 Impact factor: 4.878

The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin?

1. MODOMICS: An Operational Guide to the Use of the RNA Modification Pathways Database.

Review 2. Proteomic and interactomic insights into the molecular basis of cell functional diversity.

3. Dynamic changes in tRNA modifications and abundance during T cell activation.

Review 4. The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine.

5. THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder.

6. An intellectual disability-associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity.

Review 7. Mechanisms of epitranscriptomic gene regulation.

8. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development.

9. Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression.

10. Multiple links between 5-methylcytosine content of mRNA and translation.