Role of nitrates in silent myocardial ischemia.

Assessment of systemic and coronary hemodynamics, myocardial metabolic and mechanical function and scintigraphic and electrocardiographic studies has provided ample evidence for the existence of asymptomatic silent myocardial ischemia in both acute and chronic coronary artery syndromes. There is growing evidence to suggest that a primary decrease in coronary blood flow, resulting from increased coronary arterial resistance, is the principal cause for spontaneous symptomatic and asymptomatic myocardial ischemia in these patients. The precise mechanism for increased coronary arterial resistance has not been clarified, and it is likely to be different in different angina syndromes but similar for both symptomatic and asymptomatic myocardial ischemia. Since nitroglycerin and nitrates can decrease coronary arterial tone and coronary artery resistance, as well as myocardial oxygen requirements, these agents have the potential to relieve episodes of silent myocardial ischemia in patients with coronary artery syndromes.