Nanoparticles in Equine Nutrition: Mechanism of Action and Application as Feed Additives.

Several concerns exist regarding horse rearing such as environmental pollution, antibiotics resistance, digestive disorders, mycotoxins contamination of animal feed, gut health management, and improvement of feed efficiency. Nanoparticles have the potential to address these issues and thus could be used as feed additive. Citrate reduces and stabilizes gold nanoparticles, alongside biosynthesized silver nanoparticles have the potential to prolong and improve digestive enzyme activity, which would enhance starch digestibility in the stomach. Zinc oxide and selenium nanoparticles could be used to improve feed digestibility and volatile fatty acids production. Magnesium oxide, silver, and copper nanoparticles exhibit strong antimicrobial activity against gram-positive and gram-negative microbes and weaken the biofilm formation of the microbial community. Calcium, zinc, and silver nanoparticles could be used to prevent periodontal disease in horses. In addition, silver nanoparticles may be applied as antifasciolitics and potentially against other gastrointestinal parasites. Environmental concern of equines could be addressed by using cerium oxide, silver, and cobalt nanoparticles to reduce methane emission and zinc oxide could help to reduce fecal mineral output. Fullerol C60[OH]24, a honey-derived silver nanoparticle and zinc oxide nanoparticles exhibit attractive antibacterial properties because of increased specific surface area as the reduced particle enhance unit surface reactivity. Gut health management of equines could be solved with nanoparticles because of the ability of ferrous oxide and copper nanoparticles to improve microbial growth, whereas zinc oxide improves villus height, crypt depth, and villous surface area. It is required to explore in depth the beneficial effects of these nanoparticles as a novel area in the equine industry's both in vitro and in vivo before recommendation to equine owners.