Literature DB >> 3120367

Comparative studies of the infection of Lewis rats with four Trypanosoma cruzi clones.

M Postan1, J P McDaniel, J A Dvorak.   

Abstract

Quantitative and qualitative differences in parasitaemia levels and histopathological characteristics occurred in Lewis rats infected with four Trypanosoma cruzi clones. Rats infected with clone Sylvio-X10/7 sustained high parasitaemias and died during the acute phase whereas rats infected with clones Sylvio-X10/4, Miranda/78 or Miranda/80 did not. Myocardial fibrosis was more extensive in rats chronically infected with clone X10/4 than in rats infected with the 2 Miranda clones. Myocardial fibrosis developed more rapidly in rats than has been reported in mice. These characteristics are advantageous in developing animal models of human chagasic myocardiopathy.

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Year:  1987        PMID： 3120367     DOI： 10.1016/0035-9203(87)90155-6

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  6 in total

1.  Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

Authors:  Denise da Gama Jaén Batista; Marcos Meuser Batista; Gabriel Melo de Oliveira; Patrícia Borges do Amaral; Joseli Lannes-Vieira; Constança Carvalho Britto; Angela Junqueira; Marli Maria Lima; Alvaro José Romanha; Policarpo Ademar Sales Junior; Chad E Stephens; David W Boykin; Maria de Nazaré Correia Soeiro
Journal:  Antimicrob Agents Chemother       Date:  2010-05-10       Impact factor: 5.191

2.  Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease.

Authors:  R T Gazzinelli; V M Leme; J R Cancado; G Gazzinelli; J Scharfstein
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

3.  Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy.

Authors:  B Chandrasekar; P C Melby; D A Troyer; J T Colston; G L Freeman
Journal:  Am J Pathol       Date:  1998-04       Impact factor: 4.307

4.  Differential regulation of nitric oxide synthase isoforms in experimental acute chagasic cardiomyopathy.

Authors:  B Chandrasekar; P C Melby; D A Troyer; G L Freeman
Journal:  Clin Exp Immunol       Date:  2000-07       Impact factor: 4.330

5.  Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: a dog model.

Authors:  Alberto Barbabosa-Pliego; Hector M Díaz-Albiter; Laucel Ochoa-García; Esteban Aparicio-Burgos; Sandra M López-Heydeck; Valente Velásquez-Ordoñez; Raul C Fajardo-Muñoz; Sandra Díaz-González; Roberto Montes De Oca-Jimenez; Marco Barbosa-Mireles; Carmen Guzmán-Bracho; Jose G Estrada-Franco; Nisha Jain Garg; Juan C Vázquez-Chagoyán
Journal:  Am J Trop Med Hyg       Date:  2009-09       Impact factor: 2.345

6.  IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction.

Authors:  André Luis Bombeiro; Lígia Antunes Gonçalves; Carlos Penha-Gonçalves; Claudio Romero Farias Marinho; Maria Regina D'Império Lima; Gerson Chadi; José Maria Álvarez
Journal:  PLoS One       Date:  2012-11-12       Impact factor: 3.240
  6 in total

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