Literature DB >> 31203609

Chloride Control of the Mechanism of Human Serum Ceruloplasmin (Cp) Catalysis.

Shiliang Tian1, Stephen M Jones1, Anex Jose1, Edward I Solomon1.   

Abstract

Unraveling the mechanism of ceruloplasmin (Cp) is fundamentally important toward understanding the pathogenesis of metal-mediated diseases and metal neurotoxicity. Here we report that Cl-, the most abundant anion in blood plasma, is a key component of Cp catalysis. Based on detailed spectroscopic analyses, Cl- preferentially interacts with the partially reduced trinuclear Cu cluster (TNC) in Cp under physiological conditions and shifts the electron equilibrium distribution among the two redox active type 1 (T1) Cu sites and the TNC. This shift in potential enables the intramolecular electron transfer (IET) from the T1 Cu to the native intermediate (NI) and accelerates the IET from the T1 Cu to the TNC, resulting in faster turnover in Cp catalysis.

Entities:  

Year:  2019        PMID： 31203609      PMCID： PMC6657493          DOI： 10.1021/jacs.9b03661

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  32 in total

1.  Multicopper Oxidases and Oxygenases.

Authors:  Edward I. Solomon; Uma M. Sundaram; Timothy E. Machonkin
Journal:  Chem Rev       Date:  1996-11-07       Impact factor: 60.622

2.  Identification of catalytically important amino acids in human ceruloplasmin by site-directed mutagenesis.

Authors:  Mark A Brown; Leisa M Stenberg; A Grant Mauk
Journal:  FEBS Lett       Date:  2002-06-05       Impact factor: 4.124

3.  Increased lipid peroxidation in the brains of aceruloplasminemia patients.

Authors:  K Yoshida; K Kaneko; H Miyajima; T Tokuda; A Nakamura; M Kato; S Ikeda
Journal:  J Neurol Sci       Date:  2000-04-15       Impact factor: 3.181

Review 4.  Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis.

Authors:  Xueying Xu; Sokhon Pin; Muraya Gathinji; Ralph Fuchs; Z Leah Harris
Journal:  Ann N Y Acad Sci       Date:  2004-03       Impact factor: 5.691

5.  Steady-state kinetics of laccasse from Rhus vernicifera.

Authors:  L C Petersen; H Degn
Journal:  Biochim Biophys Acta       Date:  1978-09-11

6.  Intramolecular electron transport in human ferroxidase (caeruloplasmin).

Authors:  M De Ley; S Osaki
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

7.  The multifunctional oxidase activity of ceruloplasmin as revealed by anion binding studies.

Authors:  G Musci; G C Bellenchi; L Calabrese
Journal:  Eur J Biochem       Date:  1999-10

8.  An X-ray crystallographic study of the binding sites of the azide inhibitor and organic substrates to ceruloplasmin, a multi-copper oxidase in the plasma.

Authors:  V N Zaitsev; I Zaitseva; M Papiz; P F Lindley
Journal:  J Biol Inorg Chem       Date:  1999-10       Impact factor: 3.358

9.  Nature of the intermediate formed in the reduction of O(2) to H(2)O at the trinuclear copper cluster active site in native laccase.

Authors:  Sang-Kyu Lee; Serena DeBeer George; William E Antholine; Britt Hedman; Keith O Hodgson; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2002-05-29       Impact factor: 15.419

10.  Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury.

Authors:  Bharatkumar N Patel; Robert J Dunn; Suh Young Jeong; Qinzhang Zhu; Jean-Pierre Julien; Samuel David
Journal:  J Neurosci       Date:  2002-08-01       Impact factor: 6.167
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  5 in total

1.  Serum Ceruloplasmin Is the Candidate Predictive Biomarker for Acute Aortic Dissection and Is Related to Thrombosed False Lumen: a Propensity Score-Matched Observational Case-Control Study.

Authors:  Changcheng Ma; Haibin Zhao; Feng Shi; Mu Li; Xun Liu; Chao Ji; Yanshuo Han
Journal:  Biol Trace Elem Res       Date:  2020-06-05       Impact factor: 3.738

2.  Electron Transfer to the Trinuclear Copper Cluster in Electrocatalysis by the Multicopper Oxidases.

Authors:  Alina Sekretareva; Shiliang Tian; Sébastien Gounel; Nicolas Mano; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2021-10-11       Impact factor: 16.383

3.  Rapid Decay of the Native Intermediate in the Metallooxidase Fet3p Enables Controlled FeII Oxidation for Efficient Metabolism.

Authors:  Stephen M Jones; David E Heppner; Kenny Vu; Daniel J Kosman; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2020-05-22       Impact factor: 15.419

Review 4.  Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology.

Authors:  Zhidong Liu; Miao Wang; Chunbo Zhang; Shigao Zhou; Guang Ji
Journal:  Diabetes Metab Syndr Obes       Date:  2022-03-03       Impact factor: 3.168

5.  Encapsulation of tricopper cluster in a synthetic cryptand enables facile redox processes from CuICuICuI to CuIICuIICuII states.

Authors:  Weiyao Zhang; Curtis E Moore; Shiyu Zhang
Journal:  Chem Sci       Date:  2020-12-26       Impact factor: 9.825
  5 in total

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