Wallis Bavière1,2, Xavier Deprez1,2, Eric Houvenagel1,2, Peggy Philippe1,2, Valerie Deken1,2, Rene-Marc Flipo1,2, Julien Paccou3,4. 1. From Service de rhumatologie, Centre Hospitalier Universitaire (CHU) Lille, Lille; Service de rhumatologie, CH de Valenciennes, Valenciennes; Service de rhumatologie, Hôpital Saint-Philibert, Lomme; Département de Biostatistiques, EA 2694 - Santé publique: épidémiologie et qualité des soins, Université de Lille, CHU Lille, Lille, France. 2. W. Bavière, MD, Service de rhumatologie, CHU Lille; X. Deprez, MD, Service de rhumatologie, CH de Valenciennes; E. Houvenagel, MD, Service de rhumatologie, Hôpital Saint-Philibert; P. Philippe, MD, Service de rhumatologie, CHU Lille; V. Deken, PhD, Département de Biostatistiques, EA 2694 - Santé publique: épidémiologie et qualité des soins, Université de Lille, CHU Lille; R.M. Flipo, MD, Service de rhumatologie, CHU Lille; J. Paccou, MD, PhD, Service de rhumatologie, CHU Lille. 3. From Service de rhumatologie, Centre Hospitalier Universitaire (CHU) Lille, Lille; Service de rhumatologie, CH de Valenciennes, Valenciennes; Service de rhumatologie, Hôpital Saint-Philibert, Lomme; Département de Biostatistiques, EA 2694 - Santé publique: épidémiologie et qualité des soins, Université de Lille, CHU Lille, Lille, France. julien.paccou@chru-lille.fr. 4. W. Bavière, MD, Service de rhumatologie, CHU Lille; X. Deprez, MD, Service de rhumatologie, CH de Valenciennes; E. Houvenagel, MD, Service de rhumatologie, Hôpital Saint-Philibert; P. Philippe, MD, Service de rhumatologie, CHU Lille; V. Deken, PhD, Département de Biostatistiques, EA 2694 - Santé publique: épidémiologie et qualité des soins, Université de Lille, CHU Lille; R.M. Flipo, MD, Service de rhumatologie, CHU Lille; J. Paccou, MD, PhD, Service de rhumatologie, CHU Lille. julien.paccou@chru-lille.fr.
Abstract
OBJECTIVE: In psoriatic arthritis (PsA), comorbidities add to the burden of disease, which may lead to poorer quality of life. The purpose of this study was to evaluate the relationship between comorbidities and quality of life (QOL). METHODS: Patients from a multicentric, cross-sectional study on comorbidities in PsA were included in the analysis. Data on comorbidities were collected and were subsequently used to compute the modified Rheumatic Disease Comorbidity Index (mRDCI). The Medical Outcomes Study Short Form-36 questionnaire physical (PCS) and mental component summary (MCS) scales were used to assess QOL. RESULTS: In total, 124 recruited patients fulfilled the ClASsification for Psoriatic ARthritis criteria (CASPAR): 62.1% were male; mean age and mean disease duration were 52.6 ± 12.6 years and 11.3 ± 9.6 years, respectively. The number of comorbid conditions was 2.0 ± 1.3, with 30.6% of the sample having currently or a history of 3 or more comorbidities. In the multivariate linear regression analysis, only anxiety remained significantly related to mental health (p < 0.0001). Anxiety alone accounted for 28.7% of the variance in MCS scores. Moreover, MCS was also significantly associated with the mRDCI score, which explained 4.9% of the variance in MCS [β = -1.56 (standard error 0.64), R2 = 0.049, p = 0.0167]. In contrast, PCS was not significantly associated either with type or number of comorbidities. CONCLUSION: In this study, the type of comorbidity appeared to have a greater effect than the number of comorbidities. Indeed, anxiety in PsA was independently associated with QOL and would thus be an important factor to take into account in daily clinical practice.
OBJECTIVE: In psoriatic arthritis (PsA), comorbidities add to the burden of disease, which may lead to poorer quality of life. The purpose of this study was to evaluate the relationship between comorbidities and quality of life (QOL). METHODS:Patients from a multicentric, cross-sectional study on comorbidities in PsA were included in the analysis. Data on comorbidities were collected and were subsequently used to compute the modified Rheumatic Disease Comorbidity Index (mRDCI). The Medical Outcomes Study Short Form-36 questionnaire physical (PCS) and mental component summary (MCS) scales were used to assess QOL. RESULTS: In total, 124 recruited patients fulfilled the ClASsification for Psoriatic ARthritis criteria (CASPAR): 62.1% were male; mean age and mean disease duration were 52.6 ± 12.6 years and 11.3 ± 9.6 years, respectively. The number of comorbid conditions was 2.0 ± 1.3, with 30.6% of the sample having currently or a history of 3 or more comorbidities. In the multivariate linear regression analysis, only anxiety remained significantly related to mental health (p < 0.0001). Anxiety alone accounted for 28.7% of the variance in MCS scores. Moreover, MCS was also significantly associated with the mRDCI score, which explained 4.9% of the variance in MCS [β = -1.56 (standard error 0.64), R2 = 0.049, p = 0.0167]. In contrast, PCS was not significantly associated either with type or number of comorbidities. CONCLUSION: In this study, the type of comorbidity appeared to have a greater effect than the number of comorbidities. Indeed, anxiety in PsA was independently associated with QOL and would thus be an important factor to take into account in daily clinical practice.
Entities:
Keywords:
COMORBIDITIES; PSORIATIC ARTHRITIS; QUALITY OF LIFE
Authors: Veerle Stouten; Sofia Pazmino; P Verschueren; Pavlos Mamouris; René Westhovens; Kurt de Vlam; Delphine Bertrand; Kristien Van der Elst; Bert Vaes; Diederik De Cock Journal: RMD Open Date: 2021-06