Tien Viet Dung Vu1, Thi Thuy Nga Do2, Ulf Rydell3, Lennart E Nilsson4, Linus Olson5, Mattias Larsson6, Håkan Hanberger7, Marc Choisy8, Tuyet Trinh Dao9, H Rogier van Doorn2, Van Kinh Nguyen9, Vu Trung Nguyen9, Heiman F L Wertheim10. 1. Oxford University Clinical Research Unit, Viet Nam. Electronic address: dungvtv@oucru.org. 2. Oxford University Clinical Research Unit, Viet Nam. 3. Linköping University, Linköping, Sweden. 4. Linköping University, Linköping, Sweden; Department of Infectious Diseases, Institution of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Sweden. 5. Department of Public Health Sciences, Karolinska Institutet, Sweden; The Training and Research Academic Collaboration Sweden-Viet Nam, Hanoi, Viet Nam. 6. Oxford University Clinical Research Unit, Viet Nam; Department of Public Health Sciences, Karolinska Institutet, Sweden; The Training and Research Academic Collaboration Sweden-Viet Nam, Hanoi, Viet Nam. 7. Linköping University, Linköping, Sweden; Department of Infectious Diseases, Institution of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Sweden; The Training and Research Academic Collaboration Sweden-Viet Nam, Hanoi, Viet Nam. 8. Oxford University Clinical Research Unit, Viet Nam; MIVEGEC, French National Research Institute for Sustainable Development, Montpellier, France; The French National Centre for Scientific Research, Montpellier, France; University of Montpellier, Montpellier, France. 9. National Hospital for Tropical Diseases, Hanoi, Viet Nam. 10. Oxford University Clinical Research Unit, Viet Nam; Department of Medical Microbiology and Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, Netherlands.
Abstract
OBJECTIVE: To establish a hospital-based surveillance network with national coverage for antimicrobial resistance (AMR) and antibiotic consumption in Viet Nam. METHODS: A 16-hospital network (Viet Nam Resistance: VINARES) was established and consisted of national and provincial-level hospitals across the country. Antimicrobial susceptibility testing results from routine clinical diagnostic specimens and antibiotic consumption data in Defined Daily Dose per 1000 bed days (DDD/1000 patient-days) were prospectively collected and analysed between October 2012 and September 2013. RESULTS: Data from a total of 24 732 de-duplicated clinical isolates were reported. The most common bacteria were: Escherichia coli (4437 isolates, 18%), Klebsiella spp. (3290 isolates, 13%) and Acinetobacter spp. (2895 isolates, 12%). The hospital average antibiotic consumption was 918 DDD/1000 patient-days. Third-generation cephalosporins were the most frequently used antibiotic class (223 DDD/1000 patient-days, 24%), followed by fluoroquinolones (151 DDD/1000 patient-days, 16%) and second-generation cephalosporins (112 DDD/1000 patient-days, 12%). Proportions of antibiotic resistance were high: 1098/1580 (69%) Staphylococcus aureus isolates were methicillin-resistant (MRSA); 115/344 isolates (33%) and 90/358 (25%) Streptococcus pneumoniae had reduced susceptibility to penicillin and ceftriaxone, respectively. A total of 180/2977 (6%) E. coli and 242/1526 (16%) Klebsiella pneumoniae were resistant to imipenem, respectively; 602/1826 (33%) Pseudomonas aeruginosa were resistant to ceftazidime and 578/1765 (33%) to imipenem. Of Acinetobacter spp. 1495/2138 (70%) were resistant to carbapenems and 2/333 (1%) to colistin. CONCLUSIONS: These data are valuable in providing a baseline for AMR among common bacterial pathogens in Vietnamese hospitals and to assess the impact of interventions.
OBJECTIVE: To establish a hospital-based surveillance network with national coverage for antimicrobial resistance (AMR) and antibiotic consumption in Viet Nam. METHODS: A 16-hospital network (Viet Nam Resistance: VINARES) was established and consisted of national and provincial-level hospitals across the country. Antimicrobial susceptibility testing results from routine clinical diagnostic specimens and antibiotic consumption data in Defined Daily Dose per 1000 bed days (DDD/1000 patient-days) were prospectively collected and analysed between October 2012 and September 2013. RESULTS: Data from a total of 24 732 de-duplicated clinical isolates were reported. The most common bacteria were: Escherichia coli (4437 isolates, 18%), Klebsiella spp. (3290 isolates, 13%) and Acinetobacter spp. (2895 isolates, 12%). The hospital average antibiotic consumption was 918 DDD/1000 patient-days. Third-generation cephalosporins were the most frequently used antibiotic class (223 DDD/1000 patient-days, 24%), followed by fluoroquinolones (151 DDD/1000 patient-days, 16%) and second-generation cephalosporins (112 DDD/1000 patient-days, 12%). Proportions of antibiotic resistance were high: 1098/1580 (69%) Staphylococcus aureus isolates were methicillin-resistant (MRSA); 115/344 isolates (33%) and 90/358 (25%) Streptococcus pneumoniae had reduced susceptibility to penicillin and ceftriaxone, respectively. A total of 180/2977 (6%) E. coli and 242/1526 (16%) Klebsiella pneumoniae were resistant to imipenem, respectively; 602/1826 (33%) Pseudomonas aeruginosa were resistant to ceftazidime and 578/1765 (33%) to imipenem. Of Acinetobacter spp. 1495/2138 (70%) were resistant to carbapenems and 2/333 (1%) to colistin. CONCLUSIONS: These data are valuable in providing a baseline for AMR among common bacterial pathogens in Vietnamese hospitals and to assess the impact of interventions.
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