Lin Ji1, Ziwei Song2, Fuhai Zeng1, Ming Hu2, Siqi Chen1, Zhongjie Qin2, Delin Xia3. 1. Department of Burn and Plastic Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou Sichuan, 646000, P.R.China. 2. Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou Sichuan, 646000, P.R.China. 3. Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou Sichuan, 646000, P.R.China.xiadelin@163.com.
Abstract
OBJECTIVE: To summarize the research progress of controlled release of angiogenic factors and osteogenic factors in bone tissue engineering. METHODS: The domestic and abroad literature on the controlled release structure of growth factors during bone regeneration in recent years was extensively reviewed and summarized. RESULTS: The sustained-release structure includes direct binding, microsphere-three-dimensional scaffold structure, core-shell structure, layer self-assembly, hydrogel, and gene carrier. A sustained-release system composed of different sustained-release structures combined with different growth factors can promote bone regeneration and angiogenesis. CONCLUSION: Due to its controllability and persistence, the growth factor sustained-release system has become a research hotspot in bone tissue engineering and has broad application prospects.
OBJECTIVE: To summarize the research progress of controlled release of angiogenic factors and osteogenic factors in bone tissue engineering. METHODS: The domestic and abroad literature on the controlled release structure of growth factors during bone regeneration in recent years was extensively reviewed and summarized. RESULTS: The sustained-release structure includes direct binding, microsphere-three-dimensional scaffold structure, core-shell structure, layer self-assembly, hydrogel, and gene carrier. A sustained-release system composed of different sustained-release structures combined with different growth factors can promote bone regeneration and angiogenesis. CONCLUSION: Due to its controllability and persistence, the growth factor sustained-release system has become a research hotspot in bone tissue engineering and has broad application prospects.
Entities:
Keywords:
Growth factor; angiogenesis; bone regeneration; controlled release
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