| Literature DB >> 31197778 |
Yu Wei Zhang1,2, Nina Cabezas-Wallscheid3.
Abstract
Healthy hematopoietic stem cells (HSCs) are capable to self-renew and reconstitute the complete hematopoietic system. Upon aging, there is an increased incidence of blood-related diseases. Age-related phenotypes have been widely studied by bone marrow transplantation experiments, where reconstitution of the transplanted cells is a direct measure of HSC activity. In this protocol we describe a competitive bone marrow transplantation assay to functionally test young and old HSCs.Entities:
Keywords: Aged; Bone marrow; Competitive; Hematopoietic stem cells; Transplants; Young
Mesh：
Year: 2019 PMID： 31197778 DOI： 10.1007/978-1-4939-9574-5_15
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745