Literature DB >> 31197588

Mechanisms of Blood Flow Regulation in the Skin during Stimulation of the Spinal Cord in Humans.

G I Lobov1, Yu P Gerasimenko2, T R Moshonkina2.   

Abstract

Changes in the blood flow in the shin skin were observed by laser Doppler flowmetry after transcutaneous electrical spinal cord stimulation (TSCS) by subthreshold bipolar pulses with a frequency of 30 Hz in 12 healthy subjects. It was found that TSCS in the area of the T11 and L1 vertebrae led to a significant increase in skin blood flow. The microcirculation rate increased by more than 85% relative to the baseline at a stimulus intensity of 90% of the motor threshold. Cutaneous blood flow activization by TSCS is implemented mainly through the antidromic stimulation of sensory nerve fibers. Nitric oxide (NO) is an important mediator that contributes to vasodilation and increase in cutaneous blood flow upon TSCS. NO is predominantly of endothelial origin.

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Year:  2019        PMID： 31197588     DOI： 10.1134/S0012496619020030

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  12 in total

1.  Human sympathetic outflows to skin and muscle target organs fluctuate concordantly over a wide range of time-varying frequencies.

Authors:  Alan Bernjak; Jian Cui; Satoshi Iwase; Tadaaki Mano; Aneta Stefanovska; Dwain L Eckberg
Journal:  J Physiol       Date:  2011-11-07       Impact factor: 5.182

2.  Role of sensory nerves in the cutaneous vasoconstrictor response to local cooling in humans.

Authors:  Gary J Hodges; J Andrew Traeger; Tri Tang; Wojciech A Kosiba; Kun Zhao; John M Johnson
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-04-27       Impact factor: 4.733

3.  Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus.

Authors:  Stephen J Carter; Gary J Hodges
Journal:  Exp Physiol       Date:  2011-09-02       Impact factor: 2.969

4.  Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study.

Authors:  Susan Harkema; Yury Gerasimenko; Jonathan Hodes; Joel Burdick; Claudia Angeli; Yangsheng Chen; Christie Ferreira; Andrea Willhite; Enrico Rejc; Robert G Grossman; V Reggie Edgerton
Journal:  Lancet       Date:  2011-05-19       Impact factor: 79.321

Review 5.  Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans.

Authors:  Nisha Charkoudian
Journal:  J Appl Physiol (1985)       Date:  2010-05-06

Review 6.  Spinal cord stimulation for chronic limb ischemia.

Authors:  Joseph J Naoum; Elias J Arbid
Journal:  Methodist Debakey Cardiovasc J       Date:  2013-04

7.  Initiation and modulation of locomotor circuitry output with multisite transcutaneous electrical stimulation of the spinal cord in noninjured humans.

Authors:  Yury Gerasimenko; Ruslan Gorodnichev; Aleksandr Puhov; Tatiana Moshonkina; Aleksandr Savochin; Victor Selionov; Roland R Roy; Daniel C Lu; V Reggie Edgerton
Journal:  J Neurophysiol       Date:  2014-11-05       Impact factor: 2.714

8.  Transcutaneous electrical spinal-cord stimulation in humans.

Authors:  Yury Gerasimenko; Ruslan Gorodnichev; Tatiana Moshonkina; Dimitry Sayenko; Parag Gad; V Reggie Edgerton
Journal:  Ann Phys Rehabil Med       Date:  2015-07-20

Review 9.  Spinal cord stimulation for lower limb ischemic pain treatment.

Authors:  Luciano Pedrini; Filippo Magnoni
Journal:  Interact Cardiovasc Thorac Surg       Date:  2007-04-06

10.  Roles of peripheral terminals of transient receptor potential vanilloid-1 containing sensory fibers in spinal cord stimulation-induced peripheral vasodilation.

Authors:  Mingyuan Wu; Naoka Komori; Chao Qin; Jay P Farber; Bengt Linderoth; Robert D Foreman
Journal:  Brain Res       Date:  2007-04-30       Impact factor: 3.252
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  2 in total

1.  Electrochemical Skin Conductance Alterations during Spinal Cord Stimulation: An Experimental Study.

Authors:  Lisa Goudman; Nieke Vets; Julie Jansen; Ann De Smedt; Maxime Billot; Philippe Rigoard; Ann Cordenier; Sebastiaan Engelborghs; Aldo Scafoglieri; Maarten Moens
Journal:  J Clin Med       Date:  2021-08-13       Impact factor: 4.964

Review 2.  Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review.

Authors:  Md Akhlasur Rahman; Niraj Singh Tharu; Sylvia M Gustin; Yong-Ping Zheng; Monzurul Alam
Journal:  J Clin Med       Date:  2022-03-11       Impact factor: 4.241
  2 in total

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