Literature DB >> 31197253

The immunobiology of MIF: function, genetics and prospects for precision medicine.

Insoo Kang1, Richard Bucala2.   

Abstract

The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by data showing that common functional polymorphisms in MIF are associated with disease susceptibility or clinical severity. MIF can regulate glucocorticoid-mediated immunosuppression and has a prominent function in cell survival signalling. Further specific functions of MIF are now being defined in different autoimmune diseases and MIF-targeted biologic therapeutics are in early-stage clinical trials. The unique structure of MIF is also directing the development of small-molecule MIF antagonists. Together, these efforts could provide a means of selectively intervening in pathogenesis and overcoming MIF-related genetic susceptibility to many rheumatic diseases.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 31197253     DOI： 10.1038/s41584-019-0238-2

Source DB:  PubMed          Journal:  Nat Rev Rheumatol        ISSN： 1759-4790            Impact factor:   20.543


  38 in total

1.  Aerosolized drug-loaded nanoparticles targeting migration inhibitory factors inhibit Pseudomonas aeruginosa-induced inflammation and biofilm formation.

Authors:  Mohammad Doroudian; Andrew O'Neill; Ciaran O'Reilly; Aisling Tynan; Leona Mawhinney; Aoife McElroy; Shanice S Webster; Ronan MacLoughlin; Yuri Volkov; Michelle E Armstrong; George A O'Toole; Adriele Prina-Mello; Seamas C Donnelly
Journal:  Nanomedicine (Lond)       Date:  2020-11-26       Impact factor: 5.307

2.  Separating cytokine twins with a small molecule.

Authors:  Jürgen Bernhagen
Journal:  J Biol Chem       Date:  2019-12-06       Impact factor: 5.157

3.  Macrophage migration inhibitory factor (MIF) and IgA anti CD74 antibodies in Indian patients with enthesitis-related arthritis category of Juvenile idiopathic arthritis.

Authors:  Anu Balakrishnan; Sanjukta Majumder; Shivika Guleria; Able Lawrence; Amita Aggarwal
Journal:  Rheumatol Int       Date:  2022-07-30       Impact factor: 3.580

4.  Association of Macrophage Migration Inhibitory Factor Gene -173 G/C Polymorphism (rs755622) with Familial Mediterranean Fever in Children.

Authors:  Nursen Cakan; Resul Yılmaz; Erhan Karaaslan; Ömer Ateş
Journal:  J Pediatr Genet       Date:  2020-11-25

5.  MIF/SCL3A2 depletion inhibits the proliferation and metastasis of colorectal cancer cells via the AKT/GSK-3β pathway and cell iron death.

Authors:  Guan Huang; Lili Ma; Lan Shen; Yan Lei; Lili Guo; Yongjian Deng; Yanqing Ding
Journal:  J Cell Mol Med       Date:  2022-05-13       Impact factor: 5.295

Review 6.  New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain.

Authors:  Miaoheng Yan; Zongmian Song; Hongwei Kou; Guowei Shang; Chunfeng Shang; Xiangrong Chen; Yanhui Ji; Deming Bao; Tian Cheng; Jinfeng Li; Xiao Lv; Hongjian Liu; Songfeng Chen
Journal:  Front Cell Dev Biol       Date:  2022-05-20

Review 7.  Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation.

Authors:  Yao-Zhong Kong; Qiyan Chen; Hui-Yao Lan
Journal:  Int J Mol Sci       Date:  2022-04-28       Impact factor: 6.208

8.  Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-β1 production in fibroblasts.

Authors:  Yuxin Zhang; Zhonglong Liu; Kexin Wang; Shenji Lu; Shuai Fan; Lili Xu; Bin Cai
Journal:  Int J Biol Sci       Date:  2021-04-29       Impact factor: 6.580

9.  Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma.

Authors:  Juan Xu; Nanhui Yu; Pan Zhao; Fangfang Wang; Jingcao Huang; Yushan Cui; Hong Ding; Yan Yang; Yuhan Gao; Ling Pan; Hong Chang; Yu Wu; Bing Xiang; Yuping Gong; Xiao Shuai; Li Hou; Liping Xie; Ting Niu; Ting Liu; Li Zhang; Weiping Liu; Wenyan Zhang; Ying Qu; Wei Lin; Yimin Zhu; Sha Zhao; Yuhuan Zheng
Journal:  Front Oncol       Date:  2021-06-29       Impact factor: 6.244

10.  Macrophage Migration Inhibitory Factor-An Innovative Indicator for Free Flap Ischemia after Microsurgical Reconstruction.

Authors:  Ioannis-Fivos Megas; David Simons; Bong-Sung Kim; Christian Stoppe; Andrzej Piatkowski; Panagiotis Fikatas; Paul Christian Fuchs; Jacqueline Bastiaanse; Norbert Pallua; Jürgen Bernhagen; Gerrit Grieb
Journal:  Healthcare (Basel)       Date:  2021-05-21
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.