Michela Lupo1, Libera Siciliano2, Maria Leggio3. 1. Ataxia Laboratory, IRCCS Fondazione Santa Lucia, Via Ardeatina 306-354, 00179, Rome, Italy. Electronic address: m.lupo@hsantalucia.it. 2. Sapienza University of Rome, Via dei Marsi 78, 00185, Rome, Italy. Electronic address: libera.siciliano@uniroma1.it. 3. Ataxia Laboratory, IRCCS Fondazione Santa Lucia, Via Ardeatina 306-354, 00179, Rome, Italy; Department of Psychology, Sapienza University of Rome, Via dei Marsi 78, 00185, Rome, Italy. Electronic address: maria.leggio@uniroma1.it.
Abstract
BACKGROUND: Several studies have shown cerebellar abnormalities during depressive and manic states, although the specific cerebellar role in mood fluctuations remains poorly defined. Therefore, the study of pathologies characterized by frequent mood swings, such as bipolar disorder, is of great interest to investigate the relationship between the cerebellum and mood alterations. METHODS: A systematic literature search on the occurrence of mood disorders in patients with cerebellar pathologies (1st research strategy) and on the presence of cerebellar alterations in mood disorders (2nd research strategy) was conducted using the PubMed electronic Internet database. For this systematic review all information was written based on the PRISMA-P statement. RESULTS: The results of the 1st research strategy generated 9 articles, and in one of these, a direct correlation between cerebellar damage and the onset of mood disorder was reported. The 2nd research strategy generated 14 articles that were grouped according to the patient's mood phase (manic or depressive) or diagnosis (bipolar I or bipolar II). CONCLUSIONS: The present review suggests that the cerebellum should be considered a key structure involved in the regulation of mood.
BACKGROUND: Several studies have shown cerebellar abnormalities during depressive and manic states, although the specific cerebellar role in mood fluctuations remains poorly defined. Therefore, the study of pathologies characterized by frequent mood swings, such as bipolar disorder, is of great interest to investigate the relationship between the cerebellum and mood alterations. METHODS: A systematic literature search on the occurrence of mood disorders in patients with cerebellar pathologies (1st research strategy) and on the presence of cerebellar alterations in mood disorders (2nd research strategy) was conducted using the PubMed electronic Internet database. For this systematic review all information was written based on the PRISMA-P statement. RESULTS: The results of the 1st research strategy generated 9 articles, and in one of these, a direct correlation between cerebellar damage and the onset of mood disorder was reported. The 2nd research strategy generated 14 articles that were grouped according to the patient's mood phase (manic or depressive) or diagnosis (bipolar I or bipolar II). CONCLUSIONS: The present review suggests that the cerebellum should be considered a key structure involved in the regulation of mood.
Authors: Frank Van Overwalle; Mario Manto; Zaira Cattaneo; Silvia Clausi; Chiara Ferrari; John D E Gabrieli; Xavier Guell; Elien Heleven; Michela Lupo; Qianying Ma; Marco Michelutti; Giusy Olivito; Min Pu; Laura C Rice; Jeremy D Schmahmann; Libera Siciliano; Arseny A Sokolov; Catherine J Stoodley; Kim van Dun; Larry Vandervert; Maria Leggio Journal: Cerebellum Date: 2020-12 Impact factor: 3.847
Authors: Naushaba Hasin; Lace M Riggs; Tatyana Shekhtman; Justin Ashworth; Robert Lease; Rediet T Oshone; Elizabeth M Humphries; Judith A Badner; Pippa A Thomson; David C Glahn; David W Craig; Howard J Edenberg; Elliot S Gershon; Francis J McMahon; John I Nurnberger; Peter P Zandi; John R Kelsoe; Jared C Roach; Todd D Gould; Seth A Ament Journal: Mol Psychiatry Date: 2022-05-11 Impact factor: 15.992
Authors: Tom Chambers; Valentina Escott-Price; Sophie Legge; Emily Baker; Krish D Singh; James T R Walters; Xavier Caseras; Richard J L Anney Journal: Mol Psychiatry Date: 2022-01-25 Impact factor: 13.437
Authors: Giusy Olivito; Michela Lupo; Andrea Gragnani; Marco Saettoni; Libera Siciliano; Corinna Pancheri; Matteo Panfili; Mara Cercignani; Marco Bozzali; Roberto Delle Chiaie; Maria Leggio Journal: Cerebellum Date: 2021-08-25 Impact factor: 3.648
Authors: Michela Lupo; Giusy Olivito; Andrea Gragnani; Marco Saettoni; Libera Siciliano; Corinna Pancheri; Matteo Panfili; Marco Bozzali; Roberto Delle Chiaie; Maria Leggio Journal: Int J Mol Sci Date: 2021-03-29 Impact factor: 5.923