Literature DB >> 31194938

A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

Kanta Subbarao1, Ian Barr2.   

Abstract

The majority of influenza vaccines are produced in embryonated eggs, but mutations occur as human influenza A(H3N2) viruses adapt to grow in eggs. This can alter virus antigenicity. Wu et al. (2019) reveal that there are two mutually exclusive pathways for egg adaptation, which has potential implications for future egg-based influenza vaccines.
Copyright © 2019. Published by Elsevier Inc.

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Year:  2019        PMID： 31194938     DOI： 10.1016/j.chom.2019.05.012

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  6 in total

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2.  Differential Antibody Recognition of H3N2 Vaccine and Seasonal Influenza Virus Strains Based on Age, Vaccine Status, and Sex in the 2017-2018 Season.

Authors:  Rebecca L Ursin; Hsuan Liu; Harrison R Powell; Jason W Westerbeck; Kathryn Shaw-Saliba; Kristyn E Sylvia; Katherine J Fenstermacher; Tom Mehoke; Peter Thielen; Richard E Rothman; Andrew Pekosz; Sabra L Klein
Journal:  J Infect Dis       Date:  2020-09-14       Impact factor: 5.226

3.  Influenza Vaccines: Successes and Continuing Challenges.

Authors:  Tanja Becker; Husni Elbahesh; Leslie A Reperant; Guus F Rimmelzwaan; Albert D M E Osterhaus
Journal:  J Infect Dis       Date:  2021-09-30       Impact factor: 5.226

4.  Induction of Cross-Reactive Hemagglutination Inhibiting Antibody and Polyfunctional CD4+ T-Cell Responses by a Recombinant Matrix-M-Adjuvanted Hemagglutinin Nanoparticle Influenza Vaccine.

Authors:  Vivek Shinde; Rongman Cai; Joyce Plested; Iksung Cho; Jamie Fiske; Xuan Pham; Mingzhu Zhu; Shane Cloney-Clark; Nan Wang; Haixia Zhou; Bin Zhou; Nita Patel; Michael J Massare; Amy Fix; Michelle Spindler; David Nigel Thomas; Gale Smith; Louis Fries; Gregory M Glenn
Journal:  Clin Infect Dis       Date:  2021-12-06       Impact factor: 9.079

5.  Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells.

Authors:  Rebecca L Ursin; Santosh Dhakal; Hsuan Liu; Sahana Jayaraman; Han-Sol Park; Harrison R Powell; Morgan L Sherer; Kirsten E Littlefield; Ashley L Fink; Zexu Ma; Alice L Mueller; Allison P Chen; Kumba Seddu; Yishak A Woldetsadik; Patricia J Gearhart; H Benjamin Larman; Robert W Maul; Andrew Pekosz; Sabra L Klein
Journal:  mBio       Date:  2022-07-20       Impact factor: 7.786

6.  Recombinant Haemagglutinin Derived From the Ciliated Protozoan Tetrahymena thermophila Is Protective Against Influenza Infection.

Authors:  Karina Jawinski; Marcus Hartmann; Charanjit Singh; Ekaterina Kinnear; David C Busse; Annalisa Ciabattini; Fabio Fiorino; Donata Medaglini; Claudia Maria Trombetta; Emanuele Montomoli; Vanessa Contreras; Roger Le Grand; Celine Coiffier; Charlotte Primard; Bernard Verrier; John S Tregoning
Journal:  Front Immunol       Date:  2019-11-13       Impact factor: 7.561
  6 in total

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