Lili Huang1, Xiaoling Yu2, Li Li3, Yuanhua Chen4, Yuanyuan Yang3, Yuying Yang1, Yan Hu1, Yangyang Zhao1, Haishan Tang1, Dexiang Xu5, Mei Zhao6. 1. School of Nursing, Anhui Medical University, Hefei, China. 2. Second Affiliated Hospital, Anhui Medical University, Hefei, China. 3. First Affiliated Hospital, Anhui Medical University, Hefei, China. 4. Department of Histology and Embryology, Anhui Medical University, Hefei, China. 5. School of Public Health, Anhui Medical University, Hefei, China. 6. School of Nursing, Anhui Medical University, Hefei, China. zhaomei@ahmu.edu.cn.
Abstract
BACKGROUND AND OBJECTIVES: Increased consumption of folic acid is prevalent, raising concerns about possible adverse effects. This prospective study aimed to explore the associations between the duration of folic acid supplementation and the risk of gestational diabetes mellitus (GDM) in Chinese women. METHODS AND STUDY DESIGN: A total of 326 pregnant women were prospectively included for detailed information on folic acid supplementation during pre-pregnancy and early pregnancy, lipid profiles at 16-18 weeks, and subsequent GDM diagnosis at 24-28 weeks. Associations among folic acid supplementation, lipid profiles, and risk of GDM were analyzed using linear and logistic regression models, adjusting for potential confounders. RESULTS: The incidence of GDM in participants was 10.1%. We observed a U-shape relation between duration of folic acid supplementation and risk of GDM. Women who did not take folic acid and took folic acid for >90 days had a higher incidence of GDM compared to those who took folic acid for <=60 days. Moreover, lipid profiles were positively correlated with duration of folic acid supplementation and risk of GDM. After adjusting for demographic characters, energy and nutrients intakes and lipid profiles, the adjusted OR of GDM comparing taking folic acid for >90 days with taking folic acid for <=60 days was 3.45 (95% CI: 1.01, 11.8). CONCLUSIONS: This prospective study indicate a positive association among prolonged folic acid supplementation, lipid profiles in the second trimester, and risk of GDM. Future studies are warranted to verify the causal relationship and underlying mechanisms.
BACKGROUND AND OBJECTIVES: Increased consumption of folic acid is prevalent, raising concerns about possible adverse effects. This prospective study aimed to explore the associations between the duration of folic acid supplementation and the risk of gestational diabetes mellitus (GDM) in Chinese women. METHODS AND STUDY DESIGN: A total of 326 pregnant women were prospectively included for detailed information on folic acid supplementation during pre-pregnancy and early pregnancy, lipid profiles at 16-18 weeks, and subsequent GDM diagnosis at 24-28 weeks. Associations among folic acid supplementation, lipid profiles, and risk of GDM were analyzed using linear and logistic regression models, adjusting for potential confounders. RESULTS: The incidence of GDM in participants was 10.1%. We observed a U-shape relation between duration of folic acid supplementation and risk of GDM. Women who did not take folic acid and took folic acid for >90 days had a higher incidence of GDM compared to those who took folic acid for <=60 days. Moreover, lipid profiles were positively correlated with duration of folic acid supplementation and risk of GDM. After adjusting for demographic characters, energy and nutrients intakes and lipid profiles, the adjusted OR of GDM comparing taking folic acid for >90 days with taking folic acid for <=60 days was 3.45 (95% CI: 1.01, 11.8). CONCLUSIONS: This prospective study indicate a positive association among prolonged folic acid supplementation, lipid profiles in the second trimester, and risk of GDM. Future studies are warranted to verify the causal relationship and underlying mechanisms.
Authors: Gang Cheng; Tingting Sha; Xiao Gao; Qiong He; Xialing Wu; Qianling Tian; Fan Yang; Cai Tang; Xihong Wu; Qunhui Xie; Yan Yan Journal: Int J Environ Res Public Health Date: 2019-11-15 Impact factor: 3.390