Literature DB >> 31189781

Plant-based vaccines for Alzheimer's disease.

Shoichi Ishiura1, Taiji Yoshida2.   

Abstract

Alzheimer's disease (AD) is one of the major causes of chronic and progressive cognitive decline, with the pathological hallmarks of senile plaques and neurofibrillary tangles. Amyloid β peptide (Aβ) is the main component of senile plaques, and the pathological load of Aβ in the brain has been shown to be a marker of the severity of AD. To prevent the accumulation of plaques, novel and safer plant-based vaccine strategies have been suggested. In this review, we summarize the results of plant vaccines against Aβ.

Entities:  

Keywords:  Alzheimer’s disease; amyloid β protein; oral vaccine; plant-based vaccine

Mesh：

Substances：

Year:  2019        PMID： 31189781      PMCID： PMC6751297          DOI： 10.2183/pjab.95.020

Source DB:  PubMed          Journal:  Proc Jpn Acad Ser B Phys Biol Sci        ISSN： 0386-2208            Impact factor:   3.493


  24 in total

1.  Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization.

Authors:  J-M Orgogozo; S Gilman; J-F Dartigues; B Laurent; M Puel; L C Kirby; P Jouanny; B Dubois; L Eisner; S Flitman; B F Michel; M Boada; A Frank; C Hock
Journal:  Neurology       Date:  2003-07-08       Impact factor: 9.910

2.  Expression of amyloid-beta 1-40 and 1-42 peptides in Capsicum annum var. angulosum for oral immunization.

Authors:  Beáta Szabó; Koichi Hori; Akiko Nakajima; Noboru Sasagawa; Yuichiro Watanabe; Shoichi Ishiura
Journal:  Assay Drug Dev Technol       Date:  2004-08       Impact factor: 1.738

Review 3.  Alzheimer's disease.

Authors:  Henry W Querfurth; Frank M LaFerla
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 91.245

Review 4.  Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics.

Authors:  Dennis J Selkoe; Dale Schenk
Journal:  Annu Rev Pharmacol Toxicol       Date:  2002-01-10       Impact factor: 13.820

5.  Lessons from the 'Humanitarian Golden Rice' project: regulation prevents development of public good genetically engineered crop products.

Authors:  Ingo Potrykus
Journal:  N Biotechnol       Date:  2010-07-27       Impact factor: 5.079

6.  Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model.

Authors:  Jung Won Youm; Hee Kim; Jee Hye Lo Han; Chang Hwan Jang; Hee Jin Ha; Inhee Mook-Jung; Jae Heung Jeon; Cheol Yong Choi; Young Ho Kim; Hyun Soon Kim; Hyouk Joung
Journal:  FEBS Lett       Date:  2005-11-21       Impact factor: 4.124

7.  Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD.

Authors:  A J Bayer; R Bullock; R W Jones; D Wilkinson; K R Paterson; L Jenkins; S B Millais; S Donoghue
Journal:  Neurology       Date:  2005-01-11       Impact factor: 9.910

8.  Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

Authors:  Christoph Hock; Uwe Konietzko; Johannes R Streffer; Jay Tracy; Andri Signorell; Britta Müller-Tillmanns; Ulrike Lemke; Katharina Henke; Eva Moritz; Esmeralda Garcia; M Axel Wollmer; Daniel Umbricht; Dominique J F de Quervain; Marc Hofmann; Alessia Maddalena; Andreas Papassotiropoulos; Roger M Nitsch
Journal:  Neuron       Date:  2003-05-22       Impact factor: 17.173

9.  Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders.

Authors:  Bruno Vellas; R Black; Leon J Thal; Nick C Fox; M Daniels; G McLennan; C Tompkins; C Leibman; M Pomfret; Michael Grundman
Journal:  Curr Alzheimer Res       Date:  2009-04       Impact factor: 3.498

10.  Transgenic tomatoes expressing human beta-amyloid for use as a vaccine against Alzheimer's disease.

Authors:  Jung Won Youm; Jae Heung Jeon; Hee Kim; Young Ho Kim; Kisung Ko; Hyouk Joung; Hyunsoon Kim
Journal:  Biotechnol Lett       Date:  2008-07-05       Impact factor: 2.461
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