| Literature DB >> 31188618 |
Jingjing Shen1, Yaqin Fan1, Guoliang Zhu1, Hao Chen2, Weiming Zhu1,3, Peng Fu1,3.
Abstract
Three new polycyclic macrolactams, cyclamenols B-D (1-3), together with a known macrolactam, cyclamenol A (4), were isolated from the Streptomyces sp. OUCMDZ-4348. Their structures including absolute configurations were determined on the basis of spectroscopic analysis, chemical methods, and ECD calculations. The biosynthetic pathways involving intramolecular Diels-Alder reactions were proposed. Compound 1 exhibited selective inhibition against the gastric carcinoma cell line N87 with an IC50 value of 10.8 μM.Entities:
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Year: 2019 PMID： 31188618 DOI： 10.1021/acs.orglett.9b01710
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005