| Literature DB >> 31187655 |
Caterina Ledda1, Diana Cinà2, Sebastiano Fabio Garozzo2, Paola Senia1, Alessandro Consoli2, Andrea Marconi1, Valentina Scialfa3, Giuseppe Nunnari4, Venerando Rapisarda1.
Abstract
Tuberculosis (TB) is a diffuse communicable disease; and healthcare workers (HCWs) are among the at-risk populations for the disease. This study reports the result of TB surveillance in HCWs operating in three hospitals: one classified as 'low' risk for TB and two as 'medium' risk. A total of 2228 HCWs underwent TB screening using the standard Mantoux technique (also known as the tuberculin sensitivity test [TST]). Interferon-γ release assay (IGRA) was carried out in TST-positive subjects. Results showed an overall positivity of 21% to TST and 2% to IGRA test. TST and IGRA results were statistically associated with HCWs born after 1981. This result is due to university policies that highly recommend TB immunization. Data support the use of IGRA assay in TST-positive HCWs, in order to identify latent TB infection from vaccination.Entities:
Keywords: QuantiFERON; bacillus Calmette–Guérin; tuberculin skin test; tuberculosis
Mesh：
Year: 2019 PMID： 31187655 DOI： 10.2217/fmb-2018-0265
Source DB: PubMed Journal: Future Microbiol ISSN： 1746-0913 Impact factor: 3.165