Su-Hyun Han1, Kwang-Yeol Park1, Jeong-Min Kim1, Young Chul Youn1, Hae-Won Shin2. 1. Department of Neurology, Chung-Ang University College of Medicine, Seoul, South Korea. 2. Department of Neurology, Chung-Ang University College of Medicine, Seoul, South Korea. Electronic address: shinhw@cau.ac.kr.
Abstract
OBJECTIVE: Restless legs syndrome (RLS) has been associated with vascular diseases, including cerebrovascular and cardiovascular diseases. Among the various mechanisms in RLS, peripheral vascular endothelial dysfunction in patients with RLS has recently been proposed as a vascular pathophysiology of RLS. This study investigated arterial stiffness related to RLS in acute ischemic stroke patients and its influence on stroke outcome. METHODS: RLS in patients with acute ischemic stroke was assessed based on the four essential criteria of the International Restless Legs Syndrome Study Group described in 2003. The patients' clinical and laboratory characteristics, arterial stiffness, small vessel disease occurrence, and burden on brain MRI were recorded. Stroke severity was determined using the National Institute of Health Stroke Scale (NIHSS), and clinical outcomes were determined using the modified Rankin Scale. RESULTS: Of 296 patients with acute ischemic stroke, 16 (5.4%) were diagnosed with restless legs syndrome. Logistic regression analysis showed that a 1 m/s increase in brachial arterial pulse wave velocity was associated with the diagnosis of RLS (odds ratio, 1.092; 95% confidence interval, 1.019-1.170, p = 0.012). Diagnosis of RLS in patients with acute ischemic stroke was associated with poor clinical outcome three months after stroke (modified Rankin Scale 3-6) (odds ratio, 4.263; 95% confidence interval, 1.229-14.792, p = 0.022) along with initial NIHSS score. CONCLUSION: RLS in patients with acute ischemic stroke is associated with increased arterial stiffness and poor clinical outcomes.
OBJECTIVE:Restless legs syndrome (RLS) has been associated with vascular diseases, including cerebrovascular and cardiovascular diseases. Among the various mechanisms in RLS, peripheral vascular endothelial dysfunction in patients with RLS has recently been proposed as a vascular pathophysiology of RLS. This study investigated arterial stiffness related to RLS in acute ischemic strokepatients and its influence on stroke outcome. METHODS:RLS in patients with acute ischemic stroke was assessed based on the four essential criteria of the International Restless Legs Syndrome Study Group described in 2003. The patients' clinical and laboratory characteristics, arterial stiffness, small vessel disease occurrence, and burden on brain MRI were recorded. Stroke severity was determined using the National Institute of Health Stroke Scale (NIHSS), and clinical outcomes were determined using the modified Rankin Scale. RESULTS: Of 296 patients with acute ischemic stroke, 16 (5.4%) were diagnosed with restless legs syndrome. Logistic regression analysis showed that a 1 m/s increase in brachial arterial pulse wave velocity was associated with the diagnosis of RLS (odds ratio, 1.092; 95% confidence interval, 1.019-1.170, p = 0.012). Diagnosis of RLS in patients with acute ischemic stroke was associated with poor clinical outcome three months after stroke (modified Rankin Scale 3-6) (odds ratio, 4.263; 95% confidence interval, 1.229-14.792, p = 0.022) along with initial NIHSS score. CONCLUSION:RLS in patients with acute ischemic stroke is associated with increased arterial stiffness and poor clinical outcomes.
Authors: Félix Javier Jiménez-Jiménez; Blanca G Agúndez; Javier Gómez-Tabales; Hortensia Alonso-Navarro; Laura Turpín-Fenoll; Jorge Millán-Pascual; Mónica Díez-Fairén; Ignacio Álvarez; Pau Pastor; Marisol Calleja; Rafael García-Ruiz; Santiago Navarro-Muñoz; Marta Recio-Bermejo; José Francisco Plaza-Nieto; Esteban García-Albea; Elena García-Martín; José A G Agúndez Journal: Front Pharmacol Date: 2021-02-25 Impact factor: 5.810