Reactive oxygen species: The signal regulator of B cell.

Reactive oxygen species (ROS) are indispensable for determining the fate of immune cells in both physiological and pathogenic environments, thus stimulating the interest of immunologists and clinicians. B cells are essential in maintaining immune homeostasis, and studies have indicated that ROS affect the maturation, activation and differentiation of B cells by controlling the signaling molecules in various molecular pathways. In the present review, we aimed to summarize the biological properties of ROS and the mechanisms by which ROS regulate B cell signaling pathways. We propose that ROS and their mediated signal transduction can be a new approach for manipulating B cell immune functions.