| Literature DB >> 31184216 |
Yunjie He1, Fei Deng1, Shujie Zhao2, Shanliang Zhong3, Jianhua Zhao3, Dandan Wang1, Xiu Chen1, Jian Zhang1, Junchen Hou1, Wei Zhang1, Li Ding1, Jinhai Tang1, Zuomin Zhou4.
Abstract
Aim: Aerobic glycolysis is characteristic of breast cancer. Comprehensive expression profiles of key proteins, their prognosis and detailed relationships between miRNAs and mRNAs remain unclear. Materials & methods: Oncomine database, Kaplan-Meier overall survival and miRNA-mRNA network analysis were performed. A key miRNA was identified and explored in vitro and in vivo. Results & conclusion: Eleven key glycolytic proteins were found with higher expression and poor prognosis: GLUT1, SLC2A5, HK1, PFKP, ALDOA, TPI1, GAPDH, PGK1, ENO1, GOT1 and GOT2. Seven miRNAs were predicted targeting 11 key glycolytic proteins: miR-140-5p, miR-3064-5p, miR-152-3p, miR-449b-5p, miR-449a, miR-194-5p and miR-34a-5p. Among them, miR-140-5p was found to be downregulated in breast cancer and directly targeted GLUT1, resulting in an antiglycolytic and antiproliferative effect.Entities:
Keywords: GLUT1; SLC2A1; breast cancer; breast carcinoma; expression; glycolysis; miR-140-5p; miRNA–mRNA network; prognosis; proliferation
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Year: 2019 PMID： 31184216 DOI： 10.2217/epi-2019-0072
Source DB: PubMed Journal: Epigenomics ISSN： 1750-192X Impact factor: 4.778