| Literature DB >> 31183654 |
A V Lokhonina1,2, A V Makarov1,3, A V Elchaninov4,5, I V Arutyunyan1,6, T V Shmakova6, M V Grinberg2, N Yu Usman1, V V Surovtsev2, V P Chernikov6, T Kh Fatkhudinov1,2.
Abstract
We compared phagocytic activity of macrophages of monocyte origin and Kupffer cells under the influence of M1 and M2 inducers and without activation. Cultures of monocyte-derived macrophages and Kupffer cells were characterized by intensive expression of CD68 that was not affected by activation factors. At the same time, these cultures demonstrated different dynamics of phagocytic activity. Monocyte-derived macrophages initially had more pronounced absorption capacity that gradually increased during the experiment. Kupffer cells were characterized by abrupt fluctuations of phagocytic activity: sharp growth and rapid saturation. Despite these differences, the endosomes produced by monocyte-derived macrophages and Kupffer cells had similar degrees of maturity.Entities:
Keywords: Kupffer cells; macrophages; monocytes; phagocytosis
Mesh：
Year: 2019 PMID： 31183654 DOI： 10.1007/s10517-019-04481-5
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804