Jia-Rong Wu1, Barbara Mark2, George J Knafl2, Sandra B Dunbar3, Patricia P Chang4, Darren A DeWalt5. 1. School of Nursing, University of North Carolina at Chapel Hill, NC, United States. Electronic address: jiarongw@email.unc.edu. 2. School of Nursing, University of North Carolina at Chapel Hill, NC, United States. 3. School of Nursing, Emory University, Atlanta, GA, United States. 4. Division of Cardiology, School of Medicine, University of North Carolina at Chapel Hill, NC, United States. 5. Division of General Medicine and Clinical Epidemiology, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Abstract
BACKGROUND: Medication nonadherence is prevalent and links to serious outcomes (e.g., rehospitalization/death) in heart failure (HF) patients; therefore, an urgent need exists for an intervention to improve and sustain adherence after intervention completion. OBJECTIVES: To test the efficacy of a multi-component, family-focused, literacy-sensitive (FamLit) intervention on medication adherence in HF patients. METHODS:Forty-three HF patients and their care partners were enrolled and randomized to receive FamLit or attention-only intervention, including an in-person session at baseline and bi-weekly phone boosters for 3 months. We measured medication adherence from baseline to 3-month post-intervention using the Medication Event Monitoring System. RESULTS: After 3-month intervention, intervention patients had significantly better medication adherence than control patients. At 6 months (3-months post-intervention), intervention effect on adherence was sustained in the FamLit intervention group, while adherence decreased in the control group. CONCLUSION: Incorporating care partner support and providing an easy-to-understand intervention to patients-care partners may improve/sustain adherence.
RCT Entities:
BACKGROUND: Medication nonadherence is prevalent and links to serious outcomes (e.g., rehospitalization/death) in heart failure (HF) patients; therefore, an urgent need exists for an intervention to improve and sustain adherence after intervention completion. OBJECTIVES: To test the efficacy of a multi-component, family-focused, literacy-sensitive (FamLit) intervention on medication adherence in HF patients. METHODS: Forty-three HF patients and their care partners were enrolled and randomized to receive FamLit or attention-only intervention, including an in-person session at baseline and bi-weekly phone boosters for 3 months. We measured medication adherence from baseline to 3-month post-intervention using the Medication Event Monitoring System. RESULTS: After 3-month intervention, intervention patients had significantly better medication adherence than control patients. At 6 months (3-months post-intervention), intervention effect on adherence was sustained in the FamLit intervention group, while adherence decreased in the control group. CONCLUSION: Incorporating care partner support and providing an easy-to-understand intervention to patients-care partners may improve/sustain adherence.
Authors: Terry C Davis; Michael S Wolf; Pat F Bass; Jason A Thompson; Hugh H Tilson; Marolee Neuberger; Ruth M Parker Journal: Ann Intern Med Date: 2006-11-29 Impact factor: 25.391
Authors: Fabienne Dobbels; Sabina De Geest; Johan van Cleemput; Walter Droogne; Johan Vanhaecke Journal: J Heart Lung Transplant Date: 2004-11 Impact factor: 10.247
Authors: Michael D Murray; James Young; Shawn Hoke; Wanzhu Tu; Michael Weiner; Daniel Morrow; Kevin T Stroupe; Jingwei Wu; Daniel Clark; Faye Smith; Irmina Gradus-Pizlo; Morris Weinberger; D Craig Brater Journal: Ann Intern Med Date: 2007-05-15 Impact factor: 25.391
Authors: John D Piette; Dana Striplin; Nicolle Marinec; Jenny Chen; Ranak B Trivedi; David C Aron; Lawrence Fisher; James E Aikens Journal: J Med Internet Res Date: 2015-06-10 Impact factor: 5.428
Authors: Darren A DeWalt; Kimberly A Broucksou; Victoria Hawk; David W Baker; Dean Schillinger; Bernice Ruo; Kirsten Bibbins-Domingo; Mark Holmes; Morris Weinberger; Aurelia Macabasco-O'Connell; Michael Pignone Journal: BMC Health Serv Res Date: 2009-06-11 Impact factor: 2.655
Authors: Lochan M Shah; Jie Ding; Erin M Spaulding; William E Yang; Matthias A Lee; Ryan Demo; Francoise A Marvel; Seth S Martin Journal: J Cardiovasc Transl Res Date: 2021-05-17 Impact factor: 3.216