Aidan J C Burrell1, Victoria Bennett2, Alexis L Serra3, Vincent A Pellegrino4, Lorena Romero5, Eddy Fan6, Daniel Brodie7, D James Cooper8, David M Kaye9, John F Fraser10, Carol L Hodgson11. 1. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Department of Intensive Care, The Alfred Hospital, Melbourne, Australia. Electronic address: aidan.burrell@monash.edu. 2. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: victoria.bennett@monash.edu. 3. Division of Pulmonary, Allergy, and Critical Care, Columbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, New York, USA. Electronic address: als9220@nyp.org. 4. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Department of Intensive Care, The Alfred Hospital, Melbourne, Australia. Electronic address: V.Pellegrino@alfred.org.au. 5. The Ian Potter Library, The Alfred Hospital, Melbourne, Australia. Electronic address: L.Romero@alfred.org.au. 6. Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology, Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Canada. Electronic address: eddy.fan@uhn.ca. 7. Division of Pulmonary, Allergy, and Critical Care, Columbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, New York, USA. Electronic address: hdb5@cumc.columbia.edu. 8. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Department of Intensive Care, The Alfred Hospital, Melbourne, Australia. Electronic address: jamie.cooper@monash.edu. 9. Baker IDI Heart and Diabetes Research Institute, Melbourne, Australia. Electronic address: David.Kaye@baker.edu.au. 10. Critical Care Research Group Adult Intensive Care Service, The Prince Charles Hospital and University of Queensland, Brisbane, Australia. 11. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Department of Intensive Care, The Alfred Hospital, Melbourne, Australia. Electronic address: carol.hodgson@monash.edu.
Abstract
PURPOSE: The purpose of this study was to systematically investigate the reporting of selection criteria and outcome measures, and to examine definitions of complications used in venoarterial extracorporeal membrane oxygenation studies (V-A ECMO). MATERIALS AND METHODS: Medline, EMBASE and the Cochrane central register were searched for V-A ECMO studies from January 2005 to July 2017. Studies with ≤99 patients or without patient centered outcomes were excluded. Two reviewers independently assessed search results and undertook data extraction. RESULTS: Forty-six studies met the inclusion criteria, and all were retrospective, observational studies. Inconsistent reporting of selection criteria, ECMO management and outcome measures was common. In-hospital mortality was the most common primary outcome (41% of studies), followed by 30-day mortality (11%). Bleeding was the most frequent complication reported, most commonly defined as "bleeding requiring transfusion" (median ≥ 2 Units/day). Significant variation in reporting and definitions was also evident for vascular, neurological renal and infectious complications. CONCLUSION: This systematic review provides clinicians with the most commonly reported selection criteria, outcome measures and complications used in ECMO practice. However non-standardized definitions and inconsistent reporting limits their ability to inform practice. New consensus driven definitions of complications and patient centred outcomes are urgently needed.
PURPOSE: The purpose of this study was to systematically investigate the reporting of selection criteria and outcome measures, and to examine definitions of complications used in venoarterial extracorporeal membrane oxygenation studies (V-A ECMO). MATERIALS AND METHODS: Medline, EMBASE and the Cochrane central register were searched for V-A ECMO studies from January 2005 to July 2017. Studies with ≤99 patients or without patient centered outcomes were excluded. Two reviewers independently assessed search results and undertook data extraction. RESULTS: Forty-six studies met the inclusion criteria, and all were retrospective, observational studies. Inconsistent reporting of selection criteria, ECMO management and outcome measures was common. In-hospital mortality was the most common primary outcome (41% of studies), followed by 30-day mortality (11%). Bleeding was the most frequent complication reported, most commonly defined as "bleeding requiring transfusion" (median ≥ 2 Units/day). Significant variation in reporting and definitions was also evident for vascular, neurological renal and infectious complications. CONCLUSION: This systematic review provides clinicians with the most commonly reported selection criteria, outcome measures and complications used in ECMO practice. However non-standardized definitions and inconsistent reporting limits their ability to inform practice. New consensus driven definitions of complications and patient centred outcomes are urgently needed.
Authors: Anne Willers; Justyna Swol; Hergen Buscher; Zoe McQuilten; Sander M J van Kuijk; Hugo Ten Cate; Peter T Rycus; Stephen McKellar; Roberto Lorusso; Joseph E Tonna Journal: Crit Care Med Date: 2022-02-03 Impact factor: 9.296
Authors: Darryl Abrams; Giacomo Grasselli; Matthieu Schmidt; Thomas Mueller; Daniel Brodie Journal: Intensive Care Med Date: 2019-11-25 Impact factor: 41.787
Authors: Joppe Drop; Suelyn Van Den Helm; Paul Monagle; Enno Wildschut; Matthijs de Hoog; Sabrina T G Gunput; Fiona Newall; Heidi J Dalton; Graeme MacLaren; Vera Ignjatovic; C Heleen van Ommen Journal: Res Pract Thromb Haemost Date: 2022-03-28