| Literature DB >> 31181420 |
Izabela Przeździk1, Myrthe Faber2, Guillén Fernández3, Christian F Beckmann4, Koen V Haak5.
Abstract
Understanding the functional organisation of the hippocampus is crucial for understanding its role in cognition and disorders in which it is implicated. Different views have been proposed of how function is distributed along its long axis: one view suggests segregation, whereas the alternative view postulates a more gradual organisation. Here, we applied a novel 'connectopic mapping' data-analysis approach to the resting-state fMRI data of participants of the Human Connectome Project, and demonstrate that the functional organisation of the hippocampal longitudinal axis is gradual rather than segregated into parcels. In addition, we show that inter-individual variations in this gradual organisation predict variations in recollection memory better than a characterisation based on functional parcellation. These results present an important step forward in understanding the functional organisation of the human hippocampus and have important implications for translating between rodent and human research.Entities:
Keywords: Connectivity gradient; Connectopic mapping; Hippocampus; Longitudinal axis; Recollection
Mesh:
Year: 2019 PMID: 31181420 DOI: 10.1016/j.cortex.2019.04.015
Source DB: PubMed Journal: Cortex ISSN: 0010-9452 Impact factor: 4.027