| Literature DB >> 31181314 |
Fangrong Shen1, Lanlan Feng2, Jinhua Zhou3, Hongyu Zhang3, Yuejuan Xu3, Rong Jiang3, He Zhang3, Youguo Chen4.
Abstract
LncRNA CASC11 promotes gastric cancer and colon cancer. Our study analyzed the role of CASC11 in ovarian squamous cell carcinoma (OSCC). In the present study we showed that plasma CASC11 was upregulated in OSCC, and the upregulation of CASC11 distinguished OSCC patients from control group. Plasma levels of CASC11 were further increased after chemotherapy. Treatment with oxaliplatin, tetraplatin, cisplatin, and carboplatin mediated the upregulation of CASC11 in cells of OSCC cell line. In addition, overexpression of CASC11 led to increased cancer cell viability under oxaliplatin, tetraplatin, cisplatin, and carboplatin treatment, while CASC11 siRNA silencing played an opposite role. Therefore, overexpression of CASC11 in OSCC mediated the development of cancer cell resistance to chemotherapy.Entities:
Keywords: CASC11; Chemotherapy; Ovarian squamous cell carcinoma; Viability
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Year: 2019 PMID： 31181314 DOI： 10.1016/j.gene.2019.06.011
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688