Literature DB >> 31181146

Sleep duration and fragmentation in relation to leukocyte DNA methylation in adolescents.

Erica C Jansen1,2, Dana C Dolinoy2,3, Louise M O'Brien1,4, Karen E Peterson2, Ronald D Chervin1, Margaret Banker5, Martha María Téllez-Rojo6, Alejandra Cantoral7, Adriana Mercado-Garcia6, Brisa Sanchez8, Jaclyn M Goodrich3.   

Abstract

STUDY
OBJECTIVES: Sleep deprivation and low sleep quality are widespread among adolescents, and associate with obesity risk. Plausible mediators include diet and physical activity. Another potential interrelated pathway, as yet unexplored in adolescents, could involve epigenetic modification of metabolism genes.
METHODS: In a cohort of 351 Mexico City adolescents (47% male; mean [SD] age = 14 [2] years), 7-day actigraphy was used to assess average sleep duration, sleep fragmentation, and movement index. DNA isolated from blood leukocytes was bisulfite-converted, amplified, and pyrosequenced at four candidate regions. Linear mixed models evaluated sex-stratified associations between sleep characteristics (split into quartiles [Q]) and DNA methylation of each region, adjusted for potential confounders.
RESULTS: Mean sleep duration was 8.5 [0.8] hours for boys and 8.7 [1] hours for girls. There were sex-specific associations between sleep duration and LINE-1 (long interspersed nuclear element) methylation. Boys with longer sleep duration (Q4) had lower LINE-1 methylation than boys in the 3rd quartile reference category, while girls with both longer and shorter sleep duration had higher LINE-1 methylation compared to Q3. Longer sleep duration was associated with higher H19 methylation among girls (comparing highest to third quartile, -0.9% [-2.2, 0.5]; p, trend = 0.047). Sleep fragmentation was inversely associated with peroxisome proliferator-activated receptor alpha (PPARA) methylation among girls (comparing highest to lowest fragmentation quartile, 0.9% [0.1 to 1.8]). Girls also showed an inverse association between sleep fragmentation and hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2; Q4 to Q1, 0.6% [-1.2%, 0%]).
CONCLUSIONS: Sleep duration and fragmentation in adolescents show sex-specific associations with leukocyte DNA methylation patterns of metabolism genes. © Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  actigraphy; cardiometabolic; epigenetics; genes; metabolism; sleep quality

Mesh：

Substances：

Year:  2019        PMID： 31181146      PMCID： PMC7255500          DOI： 10.1093/sleep/zsz121

Source DB:  PubMed          Journal:  Sleep        ISSN： 0161-8105            Impact factor:   5.849


  47 in total

1.  Association of blood leukocyte DNA methylation at LINE-1 and growth-related candidate genes with pubertal onset and progression.

Authors:  Yue Wu; Karen E Peterson; Brisa N Sánchez; Dana C Dolinoy; Adriana Mercado-Garcia; Martha M Téllez-Rojo; Jaclyn M Goodrich
Journal:  Epigenetics       Date:  2018-12-22       Impact factor: 4.528

Review 2.  Murine models of sleep apnea: functional implications of altered macrophage polarity and epigenetic modifications in adipose and vascular tissues.

Authors:  Wojciech Trzepizur; Rene Cortese; David Gozal
Journal:  Metabolism       Date:  2017-11-16       Impact factor: 8.694

3.  Activity-based sleep-wake identification: an empirical test of methodological issues.

Authors:  A Sadeh; K M Sharkey; M A Carskadon
Journal:  Sleep       Date:  1994-04       Impact factor: 5.849

4.  Sex differences in the association between sleep duration, diet and body mass index: a birth cohort study.

Authors:  Fabiola Tatone-Tokuda; Lise Dubois; Timothy Ramsay; Manon Girard; Evelyne Touchette; Dominique Petit; Jacques Y Montplaisir
Journal:  J Sleep Res       Date:  2011-12-12       Impact factor: 3.981

5.  Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study.

Authors:  Hassan S Dashti; Lisette A Zuurbier; Ester de Jonge; Trudy Voortman; Paul F Jacques; Stefania Lamon-Fava; Frank A J L Scheer; Jessica C Kiefte-De Jong; Albert Hofman; José M Ordovás; Oscar H Franco; Henning Tiemeier
Journal:  J Sleep Res       Date:  2016-02-09       Impact factor: 3.981

6.  11beta-hydroxysteroid dehydrogenase 2 activity is elevated in severe obesity and negatively associated with insulin sensitivity.

Authors:  Karsten Müssig; Thomas Remer; Axel Haupt; Baptist Gallwitz; Andreas Fritsche; Hans-Ulrich Häring; Christiane Maser-Gluth
Journal:  Obesity (Silver Spring)       Date:  2008-04-10       Impact factor: 5.002

Review 7.  Early nutrition, epigenetics, and cardiovascular disease.

Authors:  Elena Loche; Susan E Ozanne
Journal:  Curr Opin Lipidol       Date:  2016-10       Impact factor: 4.776

Review 8.  Sleep Deprivation and the Epigenome.

Authors:  Marie E Gaine; Snehajyoti Chatterjee; Ted Abel
Journal:  Front Neural Circuits       Date:  2018-02-27       Impact factor: 3.492

9.  LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.

Authors:  Elena Schmidt; Ines Dhaouadi; Isabella Gaziano; Matteo Oliverio; Paul Klemm; Motoharu Awazawa; Gerfried Mitterer; Eduardo Fernandez-Rebollo; Marta Pradas-Juni; Wolfgang Wagner; Philipp Hammerschmidt; Rute Loureiro; Christoph Kiefer; Nils R Hansmeier; Sajjad Khani; Matteo Bergami; Markus Heine; Evgenia Ntini; Peter Frommolt; Peter Zentis; Ulf Andersson Ørom; Jörg Heeren; Matthias Blüher; Martin Bilban; Jan-Wilhelm Kornfeld
Journal:  Nat Commun       Date:  2018-09-06       Impact factor: 14.919

10.  Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Authors:  Jakob Wefers; Dirk van Moorsel; Jan Hansen; Niels J Connell; Bas Havekes; Joris Hoeks; Wouter D van Marken Lichtenbelt; Hélène Duez; Esther Phielix; Andries Kalsbeek; Mark V Boekschoten; Guido J Hooiveld; Matthijs K C Hesselink; Sander Kersten; Bart Staels; Frank A J L Scheer; Patrick Schrauwen
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-09       Impact factor: 11.205
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Authors:  Sara Sammallahti; M Elisabeth Koopman-Verhoeff; Anne-Claire Binter; Mònica Guxens; Rebecca C Richmond; Charlotte A M Cecil; Rosa H Mulder; Alba Cabré-Riera; Tuomas Kvist; Anni L K Malmberg; Giancarlo Pesce; Sabine Plancoulaine; Jonathan A Heiss; Sheryl L Rifas-Shiman; Stefan W Röder; Anne P Starling; Rory Wilson; Kathrin Guerlich; Kristine L Haftorn; Christian M Page; Annemarie I Luik; Henning Tiemeier; Janine F Felix; Katri Raikkonen; Jari Lahti; Caroline L Relton; Gemma C Sharp; Melanie Waldenberger; Veit Grote; Barbara Heude; Isabella Annesi-Maesano; Marie-France Hivert; Ana C Zenclussen; Gunda Herberth; Dana Dabelea; Regina Grazuleviciene; Marina Vafeiadi; Siri E Håberg; Stephanie J London
Journal:  Clin Epigenetics       Date:  2022-07-05       Impact factor: 7.259

2.  Epigenetics and the International Classification of Functioning, Disability and Health Model: Bridging Nature, Nurture, and Patient-Centered Population Health.

Authors:  Richard K Shields; Shauna Dudley-Javoroski
Journal:  Phys Ther       Date:  2022-01-01

3.  The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study.

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Journal:  Clin Epigenetics       Date:  2022-05-20       Impact factor: 7.259

4.  Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study.

Authors:  Maria Elisabeth Koopman-Verhoeff; Rosa H Mulder; Jared M Saletin; Irwin Reiss; Gijsbertus T J van der Horst; Janine F Felix; Mary A Carskadon; Henning Tiemeier; Charlotte A M Cecil
Journal:  J Child Psychol Psychiatry       Date:  2020-05-03       Impact factor: 8.982

5.  Adolescent sleep timing and dietary patterns in relation to DNA methylation of core circadian genes: a pilot study of Mexican youth.

Authors:  Erica C Jansen; Dana Dolinoy; Karen E Peterson; Louise M O'Brien; Ronald D Chervin; Alejandra Cantoral; Martha María Tellez-Rojo; Maritsa Solano-Gonzalez; Jaclyn Goodrich
Journal:  Epigenetics       Date:  2020-10-04       Impact factor: 4.528
  5 in total

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