Literature DB >> 31180685

Strain-Release Driven Cycloadditions for Rapid Construction of Functionalized Pyridines and Amino Alcohols.

Sebastian Clementson1, Alessio Radaelli1,2, Kasper Fjelbye1, David Tanner2, Mikkel Jessing1.   

Abstract

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).

Entities:  

Year:  2019        PMID: 31180685     DOI: 10.1021/acs.orglett.9b01652

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  One-Pot Synthesis of Strain-Release Reagents from Methyl Sulfones.

Authors:  Myunggi Jung; Vincent N G Lindsay
Journal:  J Am Chem Soc       Date:  2022-03-14       Impact factor: 16.383

  1 in total

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