| Literature DB >> 31179707 |
Yong Sheng Chng1,2, Geordi Tristan1, George W Yip3, Yulin Lam1,2.
Abstract
Chondroitin 6-sulfate (CS-C) is an important glycosaminoglycan that regulates many physiological functions including the development, progression, and metastasis of cancer. To understand its mechanism of action at the molecular level, CS-C molecules of defined length are required. A protecting group-free synthesis of CS-C disaccharide and tetrasaccharide from the CS-A polymer that involves only three steps and furnishes CS-O disaccharide and tetrasaccharide as intermediates is reported.Entities:
Year: 2019 PMID： 31179707 DOI： 10.1021/acs.orglett.9b01457
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005