Bernhard G Weiss1,2, Friedrich Ihler1,2,3, Mahalia Zoe Anczykowski1, Mattis Bertlich1,2, Julia Kitz4, Wolfgang Steiner1, Martin Canis1,2, Mark Jakob1,2. 1. Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, Göttingen, Germany. 2. Department of Otorhinolaryngology, Ludwig-Maximilians University of Munich, Munich, Germany. 3. German Center for Vertigo and Balance Disorders (DSGZ), Ludwig-Maximilians University of Munich, Munich, Germany. 4. Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Abstract
BACKGROUND: Oncological and functional outcome of transoral laser microsurgery (TLM) for primary treatment of oropharyngeal cancer was examined using a multimodal treatment concept. METHODS: A total of 368 patients with oropharyngeal squamous cell carcinoma (pT1-4, pN0-2, M0) underwent TLM +/- neck dissection (85%), +/- (chemo)radiotherapy (57%). The majority of patients had advanced stage III and IVa disease (79%). RESULTS: Five-year Kaplan-Meier estimates for local control were 83.5% for pT1, 74.1% for pT2, 77.3% for pT3, and 76.0% for pT4a tumors. Five-year estimates of overall, disease-specific, and recurrence-free survival for stage I were 76.0%, 92.8%, and 69.1%; for stage II 71.1%, 85.7%, and 49.6%; for stage III 61.7%, 72.5%, and 58.8%; and for stage IVa 57.3%, 73.7%, and 63.9%, respectively. Postoperative (chemo)radiotherapy improved the outcome for advanced disease. p16-positive tumors had superior survival estimates. Overall, 93.5% maintained regular oral nutrition without feeding tube dependency. CONCLUSION: Primary TLM in multimodal concepts of treatment offers good oncologic outcome even for advanced-stage oropharyngeal cancer.
BACKGROUND: Oncological and functional outcome of transoral laser microsurgery (TLM) for primary treatment of oropharyngeal cancer was examined using a multimodal treatment concept. METHODS: A total of 368 patients with oropharyngeal squamous cell carcinoma (pT1-4, pN0-2, M0) underwent TLM +/- neck dissection (85%), +/- (chemo)radiotherapy (57%). The majority of patients had advanced stage III and IVa disease (79%). RESULTS: Five-year Kaplan-Meier estimates for local control were 83.5% for pT1, 74.1% for pT2, 77.3% for pT3, and 76.0% for pT4a tumors. Five-year estimates of overall, disease-specific, and recurrence-free survival for stage I were 76.0%, 92.8%, and 69.1%; for stage II 71.1%, 85.7%, and 49.6%; for stage III 61.7%, 72.5%, and 58.8%; and for stage IVa 57.3%, 73.7%, and 63.9%, respectively. Postoperative (chemo)radiotherapy improved the outcome for advanced disease. p16-positive tumors had superior survival estimates. Overall, 93.5% maintained regular oral nutrition without feeding tube dependency. CONCLUSION: Primary TLM in multimodal concepts of treatment offers good oncologic outcome even for advanced-stage oropharyngeal cancer.
Authors: Mattis Bertlich; Nina Zeller; Saskia Freytag; Jennifer L Spiegel; Bernhard G Weiss; Martin Canis; Frank Haubner; Friedrich Ihler Journal: BMC Surg Date: 2022-05-19 Impact factor: 2.030
Authors: Francesco Barbara; Francesco Cariti; Valentina De Robertis; Michele Barbara Journal: Acta Otorhinolaryngol Ital Date: 2021-02 Impact factor: 2.124
Authors: Olivier Gires; Frank Haubner; Alexandra Blancke Soares; Robert Meier; Gregor Liebsch; Sabina Schwenk-Zieger; Martin E Kirmaier; Sebastian Theurich; Magdalena Widmann; Martin Canis Journal: Cancer Metab Date: 2021-05-04
Authors: Bernhard G Weiss; Mahalia Zoe Anczykowski; Stefan Küffer; Jennifer L Spiegel; Mattis Bertlich; Martin Canis; Friedrich Ihler; Julia Kitz; Mark Jakob Journal: Eur Arch Otorhinolaryngol Date: 2020-08-20 Impact factor: 2.503