Shinichiro Uchiyama1, Takao Hoshino2, Leila Sissani2, Monteiro Tavares Linsay2, Kenji Kamiyama3, Taizen Nakase4, Kazuo Kitagawa5, Kazuo Minematsu6, Kenichi Todo7, Yasushi Okada8, Jyoji Nakagawara6, Ken Nagata9, Hiroshi Yamagami6, Takenori Yamaguchi6, Pierre Amarenco2. 1. Clinical Research Center, International University of Health and Welfare, Center for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo, Japan. Electronic address: suchiyama@iuhw.ac.jp. 2. Department of Neurology and Stroke Center, Bichat Hospital, Paris, France. 3. Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan. 4. Department of Neurology and Stroke Science, Research Institute of Brain and Blood Vessels Akita, Akita, Japan. 5. Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan. 6. National Cerebral and Cardiovascular Center, Osaka, Japan. 7. Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan. 8. Department of Cerebrovascular Medicine and Neurology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. 9. Yokohama General Hospital, Yokohama, Japan.
Abstract
BACKGROUND: TIAregistry.org is an international cohort of patients with transient ischemic attack (TIA) or minor stroke within 7 days before enrollment in the registry. Main analyses of 1-year follow-up data have been reported.5 We conducted subanalysis on the baseline and 1-year follow-up data of Japanese patients. METHODS: The patients were classified into 2 groups based on Japanese ethnicity, Japanese (345) and non-Japanese (3238), and their baseline data and 1-year event rates were compared. We also determined risk factors and predictors of 1-year stroke. RESULTS: Current smoking, regular alcohol drinking, intracranial arterial stenosis, and small vessel occlusion; and hypertension, dyslipidemia, coronary artery disease, and extracranial arterial stenosis were more and less common among Japanese patients, respectively. Stroke risk was higher and TIA risk was lower at 1-year follow-up among Japanese patients. The baseline risk factors for recurrent stroke were diabetes, alcohol drinking, and large artery atherosclerosis. Independent predictors of 1-year stroke risk were prior congestive heart failure and alcohol consumption. CONCLUSIONS: The two populations of patients featured differences in risk factors, stroke subtypes, and outcome events. Predictors of recurrent stroke among Japanese patients included congestive heart failure and regular alcohol drinking. Strategies to attenuate residual risk of stroke aside from adherence to current guidelines should take our Japanese-patient specific findings into account.
BACKGROUND: TIAregistry.org is an international cohort of patients with transient ischemic attack (TIA) or minor stroke within 7 days before enrollment in the registry. Main analyses of 1-year follow-up data have been reported.5 We conducted subanalysis on the baseline and 1-year follow-up data of Japanese patients. METHODS: The patients were classified into 2 groups based on Japanese ethnicity, Japanese (345) and non-Japanese (3238), and their baseline data and 1-year event rates were compared. We also determined risk factors and predictors of 1-year stroke. RESULTS: Current smoking, regular alcohol drinking, intracranial arterial stenosis, and small vessel occlusion; and hypertension, dyslipidemia, coronary artery disease, and extracranial arterial stenosis were more and less common among Japanese patients, respectively. Stroke risk was higher and TIA risk was lower at 1-year follow-up among Japanese patients. The baseline risk factors for recurrent stroke were diabetes, alcohol drinking, and large artery atherosclerosis. Independent predictors of 1-year stroke risk were prior congestive heart failure and alcohol consumption. CONCLUSIONS: The two populations of patients featured differences in risk factors, stroke subtypes, and outcome events. Predictors of recurrent stroke among Japanese patients included congestive heart failure and regular alcohol drinking. Strategies to attenuate residual risk of stroke aside from adherence to current guidelines should take our Japanese-patient specific findings into account.
Authors: Xinyi Leng; Robert Hurford; Xueyan Feng; Ka Lung Chan; Frank J Wolters; Linxin Li; Yannie Oy Soo; Ka Sing Lawrence Wong; Vincent Ct Mok; Thomas W Leung; Peter M Rothwell Journal: J Neurol Neurosurg Psychiatry Date: 2021-03-30 Impact factor: 10.154