| Literature DB >> 3117826 |
C Desgranges1, J Paire, C Pichoud, S Souche, D Frommel, C Trepo.
Abstract
Peripheral blood mononuclear cells from donors immunized with hepatitis B vaccine (Pasteur Hevac B) were transformed with Epstein-Barr virus. Two polyclonal cell lines, producing antibodies to hepatitis B surface antigen were established and cloned. Seven clones were isolated; they secreted between 10 and 20 micrograms/ml of HBs specific IgG1 kappa or lambda antibody with anti-HBs titer of 300-800 IU/ml. These human antibodies expressed the anti 'a' specificities and had high affinity and avidity; their potential use as reagents for hepatitis B virus detection and for passive immunotherapy is under study.Entities:
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Year: 1987 PMID： 3117826 DOI： 10.1016/0166-0934(87)90013-9
Source DB: PubMed Journal: J Virol Methods ISSN： 0166-0934 Impact factor: 2.014