| Literature DB >> 31178140 |
Babita Dahal Lamichane1, Seok Yun Jung1, Jisoo Yun1, Songhwa Kang1, Da Yeon Kim1, Shreekrishna Lamichane2, Yeon Ju Kim1, Ji Hye Park1, Woong Bi Jang1, Seung Taek Ji1, Li Dehua1, Jong Seong Ha1, Yun Hak Kim3, Sang-Mo Kwon4.
Abstract
Colorectal cancer is one of the leading causes of cancer-related deaths. Due to relapse after current therapy regimens, cancer stem cells (CSCs) are being studied to target this small tumor-initiating population. Anterior gradient 2 (AGR2), a disulfide isomerase protein, is a well-known pro-oncogenic/metastatic oncogene overexpressed in various tumor tissues, including colon cancer. We found that AGR2 was a novel stem cell marker that was regulated by the canonical Wnt/β-catenin pathway in colon CSCs. AGR2 was highly co-expressed with surface stem cell markers in spheroidal culture. Silencing of AGR2 resulted in decreased sphere-forming ability and down-regulated expression of stem cell markers, whereas the opposite effects were seen with AGR2 overexpression. Moreover, patients with high β-catenin and AGR2 expression showed lower overall survival than those with low expression. In conclusion, our study describes a novel role for AGR2 as a stem cell marker that is highly regulated by canonical Wnt/β-catenin signaling in colorectal cancer.Entities:
Keywords: AGR2; Cancer stem cell; Colorectal cancer; Metastasis; Wnt
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Year: 2019 PMID： 31178140 DOI： 10.1016/j.bbrc.2019.05.154
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575