| Literature DB >> 31177467 |
A L Kaysheva1, A T Kopylov2, N E Kushlinskii3, E S Gershtein3, A A Alferov3, A A Morozov4, I A Kazantseva4, T O Pleshakova2, A I Archakov2, Yu D Ivanov2.
Abstract
Comparative mass spectrometric analysis of protein composition was carried out in 36 blood plasma specimens from patients with renal cell carcinoma and 20 specimens from donors. Analysis of protein composition of plasma specimens devoid of the major protein fractions showed a 20-50% higher level of protein identifications in patient' specimens. Specimens of the control and experimental series were similar by protein composition, 70-80% identifications in experimental and control series coinciding. High similarity of biological processes with participation of the proteins identified in both series was observed. The greater part of proteins in both series were located extracellularly and were exosomal (specimens from renal cancer patients) or vesicular (specimens from healthy volunteers).Entities:
Keywords: blood plasma; liquid chromato-mass-spectrometry; panoramic analysis; renal cell carcinoma
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Year: 2019 PMID： 31177467 DOI： 10.1007/s10517-019-04468-2
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804