Satoru Kase 1 , Hiroaki Endo 2 , Mitsuo Takahashi 2 , Michiyuki Saito 3 , Masahiko Yokoi 4 , Yuki Ito 4 , Satoshi Katsuta 5 , Shozo Sonoda 5 , Taiji Sakamoto 5 , Susumu Ishida 3 , Manabu Kase 2 Show Affiliations »
Abstract
PURPOSE: The aim of this study was to analyse choroidal structures in normal patients and patients with diabetes with various severities of diabetic retinopathy (DR). METHODS: This is a retrospective observation case control study. Three hundred and forty-two diabetic eyes, and age-matched 112 eyes without diabetes mellitus (DM) were enrolled in this study. Patients with DM were classified into no DR, mild/moderate non-proliferative DR (mNPDR), severe NPDR and proliferative DR (PDR). Patients with DM were further divided into two groups based on information regarding systemic DM treatment situation: DM-treated and untreated groups. Central choroidal thickness (CCT), and total choroidal area (TCA), luminal area (LA) and stromal area (SA) were determined using enhanced depth imaging optical coherence tomography and a binarisation method, respectively. The ratio of LA in the TCA was defined as L/C ratio. RESULTS: The haemoglobin A1c (HbA1c) value was significantly higher in the DM-untreated than in the DM-treated subjects. L/C ratio was significantly lower in all the diabetic eyes than control eyes (p<0.05). TCA, LA, L/C ratio and CCT were significantly greater in the DM-untreated than treated group (each p<0.05). In the DM-untreated group, TCA and LAs (p<0.05) and L/C ratio (p<0.01) were significantly lower in mNPDR subjects than normal controls (p<0.05). PDR in the DM-untreated group showed significantly larger SA and LA, and greater CCT than normal controls (each p<0.05). CONCLUSIONS: These results suggest that choroidal vasculature was initially involved at an early DR, whereas thickened LA and SA were noted in advanced DR. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
PURPOSE: The aim of this study was to analyse choroidal structures in normal patients and patients with diabetes with various severities of diabetic retinopathy (DR). METHODS: This is a retrospective observation case control study. Three hundred and forty-two diabetic eyes , and age-matched 112 eyes without diabetes mellitus (DM ) were enrolled in this study. Patients with DM were c lassified into no DR, mild/moderate non-proliferative DR (mNPDR), severe NPDR and proliferative DR (PDR). Patients with DM were further divided into two groups based on information regarding systemic DM treatment situation: DM -treated and untreated groups. Central choroidal thickness (CCT ), and total choroidal area (TCA ), luminal area (LA) and stromal area (SA ) were determined using enhanced depth imaging optical coherence tomography and a binarisation method, respectively. The ratio of LA in the TCA was defined as L /C ratio. RESULTS: The haemoglobin A1c (HbA1c) value was significantly higher in the DM -untreated than in the DM -treated subjects. L /C ratio was significantly lower in all the diabetic eyes than control eyes (p<0.05). TCA , LA, L /C ratio and CCT were significantly greater in the DM -untreated than treated group (each p<0.05). In the DM -untreated group, TCA and LAs (p<0.05) and L /C ratio (p<0.01) were significantly lower in mNPDR subjects than normal controls (p<0.05). PDR in the DM -untreated group showed significantly larger SA and LA, and greater CCT than normal controls (each p<0.05). CONCLUSIONS: These results suggest that choroidal vasculature was initially involved at an early DR, whereas thickened LA and SA were noted in advanced DR. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Entities: Chemical
Disease
Species
Keywords:
binarization; choroidal vasculature; diabetes mellitus; diabetic retinopathy
Mesh： See more »
Year: 2019
PMID： 31177190 DOI： 10.1136/bjophthalmol-2019-314273
Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638