Xiaoxue Liu1, Junfeng Jiang2, Chuanhua Yu3, Yongbo Wang4, Yi Sun5, Juan Tang6, Tong Chen7, Yongyi Bi8, Yu Liu9, Zhi-Jiang Zhang10. 1. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: liuxx019@163.com. 2. Department of Global Health, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: jiang0111@whu.edu.cn. 3. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: yuchua@163.com. 4. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: wangyb20172030@163.com. 5. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: xiaoshihansunyi@163.com. 6. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: Ttangjuan@163.com. 7. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: 18571641639@163.com. 8. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: yongyibi1010@163.com. 9. Department of Statistics and Management, School of Management, Wuhan Institute of Technology, Wuhan, China. Electronic address: lyu429@163.com. 10. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address: zhang22968@163.com.
Abstract
BACKGROUND: Bladder cancer is closely related to occupational carcinogens, and China is undergoing a rapid industrialization. However, trend of bladder cancer incidence and mortality remains unknown in China. METHODS: Incidence and mortality rates of bladder cancer (1990-2017) were collected for each 5-year age group stratified by gender (males/females) from the Global Burden of Disease (GBD) 2017 study. The average annual percentage change (AAPC) of rates were analyzed by joinpoint regression analysis; age, period and cohort effects on incidence and mortality were simultaneously estimated by age-period-cohort model. RESULTS: Through 1990-2017, age-standardized incidence rates significantly rose in men (AAPC = 0.72%, 95% CI: 0.5%, 0.9%) while decreased in women (-1.25%: -1.6%, -0.9%); age-standardized mortality rates decreased in both men (-1.09%: -1.2%, -0.9%) and women (-2.48%: -2.8%, -2.2%). The joinpoint regression analysis showed the mortality almost decreased in all age groups; while the incidence increased in men for older age groups (from 45 to 49 to 80-84). Moreover, age effect showed the incidence and mortality increased with age; the incidence and mortality increased with time period, while in women period effect stop decreasing and began to increase since 2007; cohort effect showed them decreased with birth cohorts. CONCLUSIONS: The incidence of bladder cancer is increasing in men but mortality decreases in both sexes. Both the incidence and mortality in men substantially increase with age and period, while the rates in women increased with period since 2007. The period effect may indicate the increased risks to bladder cancer in Chinese men. Etiological studies are needed to identify the factors driving these trends of bladder cancer.
BACKGROUND:Bladder cancer is closely related to occupational carcinogens, and China is undergoing a rapid industrialization. However, trend of bladder cancer incidence and mortality remains unknown in China. METHODS: Incidence and mortality rates of bladder cancer (1990-2017) were collected for each 5-year age group stratified by gender (males/females) from the Global Burden of Disease (GBD) 2017 study. The average annual percentage change (AAPC) of rates were analyzed by joinpoint regression analysis; age, period and cohort effects on incidence and mortality were simultaneously estimated by age-period-cohort model. RESULTS: Through 1990-2017, age-standardized incidence rates significantly rose in men (AAPC = 0.72%, 95% CI: 0.5%, 0.9%) while decreased in women (-1.25%: -1.6%, -0.9%); age-standardized mortality rates decreased in both men (-1.09%: -1.2%, -0.9%) and women (-2.48%: -2.8%, -2.2%). The joinpoint regression analysis showed the mortality almost decreased in all age groups; while the incidence increased in men for older age groups (from 45 to 49 to 80-84). Moreover, age effect showed the incidence and mortality increased with age; the incidence and mortality increased with time period, while in women period effect stop decreasing and began to increase since 2007; cohort effect showed them decreased with birth cohorts. CONCLUSIONS: The incidence of bladder cancer is increasing in men but mortality decreases in both sexes. Both the incidence and mortality in men substantially increase with age and period, while the rates in women increased with period since 2007. The period effect may indicate the increased risks to bladder cancer in Chinese men. Etiological studies are needed to identify the factors driving these trends of bladder cancer.
Authors: Xiaobao Zhang; Can Chen; Yuxia Du; Danying Yan; Daixi Jiang; Xiaoxiao Liu; Mengya Yang; Cheng Ding; Lei Lan; Robert Hecht; Shigui Yang Journal: Front Public Health Date: 2022-06-17
Authors: Zhenzhen Lu; Weidong Ji; Yi Yin; Xinye Jin; Lu Wang; Zhongjie Li; Ning Wang; Kai Wang; Zhihang Peng Journal: BMC Public Health Date: 2021-06-05 Impact factor: 3.295