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Literature DB >> 31176163

Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD).

Xin Xin¹, Cheng Chen¹, Yi-Yang Hu², Qin Feng³.

Abstract

NAFLD is a vital health problem worldwide; however, no effective treatment is currently available for NAFLD. Intensive studies have indicated the efficacy of genistein (GE), a bioactive isoflavone extracted from soy, in treating NAFLD. In addition to its oestrogen-like effects, GE is known to have multiple molecular effects, for instance, lipid and glucose metabolism-promoting effects and activities against lipid peroxidation, inflammation, fibrosis, and NAFLD-related tumours. Here, this review summarizes the potential role of GE in the treatment and prevention of NAFLD and some of the currently known targets and signalling pathways of GE in NAFLD.

Entities: Chemical Disease

Keywords: Genistein; Non-alcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Review; Soy

Mesh：

Substances：

Year: 2019 PMID： 31176163 DOI： 10.1016/j.biopha.2019.109047

Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529

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Cited

13 in total

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Journal: Theranostics Date: 2022-05-13 Impact factor: 11.600

2. Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice.

Authors: Chian-Jiun Liou; Shu-Ju Wu; Szu-Chuan Shen; Li-Chen Chen; Ya-Ling Chen; Wen-Chung Huang
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3. Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD.

Authors: Eduardo Vilar-Gomez; Carlos Jose Pirola; Silvia Sookoian; Laura A Wilson; Patricia Belt; Tiebing Liang; Wanqing Liu; Naga Chalasani
Journal: Am J Gastroenterol Date: 2021-05-01 Impact factor: 12.045

4. Genistein Induces Adipogenic and Autophagic Effects in Rainbow Trout (Oncorhynchus mykiss) Adipose Tissue: In Vitro and In Vivo Models.

Authors: Sara Balbuena-Pecino; Esmail Lutfi; Natàlia Riera-Heredia; Esther Gasch-Navalón; Emilio J Vélez; Joaquim Gutiérrez; Encarnación Capilla; Isabel Navarro
Journal: Int J Mol Sci Date: 2020-08-16 Impact factor: 5.923

5. Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis.

Authors: Lena Seidemann; Anne Krüger; Victoria Kegel-Hübner; Daniel Seehofer; Georg Damm
Journal: Molecules Date: 2021-02-22 Impact factor: 4.411

6. Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide.

Authors: Yousra M El-Far; Ahmed E Khodir; Ziad A Emarah; Mohamed A Ebrahim; Mohammed M H Al-Gayyar
Journal: Redox Rep Date: 2022-12 Impact factor: 4.412

Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD).

1. Image-guided drug delivery of nanotheranostics for targeted lung cancer therapy.

2. Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1/AMPK signaling in obese mice.

3. Impact of the Association Between PNPLA3 Genetic Variation and Dietary Intake on the Risk of Significant Fibrosis in Patients With NAFLD.

4. Genistein Induces Adipogenic and Autophagic Effects in Rainbow Trout (Oncorhynchus mykiss) Adipose Tissue: In Vitro and In Vivo Models.

5. Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis.

6. Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide.

Review 7. Genistein-Opportunities Related to an Interesting Molecule of Natural Origin.

8. Associations of Urinary Phytoestrogen Concentrations with Nonalcoholic Fatty Liver Disease among Adults.

9. Genistein Alleviates High-Fat Diet-Induced Obesity by Inhibiting the Process of Gluconeogenesis in Mice.

Review 10. Nutraceutical Properties of Polyphenols against Liver Diseases.