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Literature DB >> 31175111

Myoclonic status epilepticus induced by cefepime overdose requiring haemodialysis.

Abstract

We report a case of cefepime neurotoxicity characterised by myoclonic status epilepticus with coma, in a context of acute renal failure and requiring one discontinuous conventional haemodialysis. Cefepime is a fourth-generation broad-spectrum cephalosporin mainly used to treat hospital-acquired Gram-negative infections. Acute neurotoxicity is an increasingly reported adverse effect which occurs predominantly in patients with renal impairment. Renal replacement therapy has been proposed to treat this condition. © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities: Chemical Disease Species

Keywords: dialysis; epilepsy and seizures; healthcare improvement and patient safety; unwanted effects/adverse reactions

Mesh：

Substances：

Year: 2019 PMID： 31175111 PMCID： PMC6557348 DOI： 10.1136/bcr-2018-228108

Source DB: PubMed Journal: BMJ Case Rep ISSN： 1757-790X

16 in total

1. Multiple-dose pharmacokinetics of cefepime in long-term hemodialysis with high-flux membranes.

Authors: S Schmaldienst; F Traunmüller; H Burgmann; A R Rosenkranz; R Thalhammer-Scherrer; W H Hörl; F Thalhammer
Journal: Eur J Clin Pharmacol Date: 2000-04 Impact factor: 2.953

2. Cefepime overdosage with neurotoxicity recovered by high-volume haemofiltration.

Authors: Julie Bresson; Catherine Paugam-Burtz; Julien Josserand; Christophe Bardin; Jean Mantz; Sebastian Pease
Journal: J Antimicrob Chemother Date: 2008-06-18 Impact factor: 5.790

3. Pharmacokinetics of cefepime in subjects with renal insufficiency.

Authors: R H Barbhaiya; C A Knupp; S T Forgue; G R Matzke; D R Guay; K A Pittman
Journal: Clin Pharmacol Ther Date: 1990-09 Impact factor: 6.875

4. Cefepime and continuous renal replacement therapy (CRRT): in vitro permeability of two CRRT membranes and pharmacokinetics in four critically ill patients.

Authors: Arantxazu Isla; Alicia Rodríguez Gascón; Javier Maynar; Alazne Arzuaga; Darío Toral; José Luis Pedraz
Journal: Clin Ther Date: 2005-05 Impact factor: 3.393

Review 5. Cefepime neurotoxicity: case report, pharmacokinetic considerations, and literature review.

Authors: Sum Lam; Irving H Gomolin
Journal: Pharmacotherapy Date: 2006-08 Impact factor: 4.705

6. Pharmacokinetics of cefepime during continuous renal replacement therapy in critically ill patients.

Authors: R S Malone; D N Fish; E Abraham; I Teitelbaum
Journal: Antimicrob Agents Chemother Date: 2001-11 Impact factor: 5.191

Review 7. Cephalosporin-induced neurotoxicity: clinical manifestations, potential pathogenic mechanisms, and the role of electroencephalographic monitoring.

Authors: Marie Francisca Grill; Rama Maganti
Journal: Ann Pharmacother Date: 2008-11-25 Impact factor: 3.154

1. Cefepime-Induced Encephalopathy With Seizures in a Pediatric Patient With End-Stage Renal Disease Rapidly Reversed by High-Efficiency Hemodialysis.

Authors: Siddharth Shah; Stephanie Bland
Journal: Cureus Date: 2021-03-12

Review 2. Prolonged Cefepime-Induced Neurotoxicity in a Patient with End-Stage Renal Disease.

Authors: Dorothy Dao Nguyen; Samuel Lai
Journal: Am J Case Rep Date: 2022-01-24

3. Cefepime-Induced Neurotoxicity in a 74-Year-Old Woman.

Authors: Samanvaya Sharma; Muzammil Khan; Muhammad Owais; Asim Haider
Journal: Cureus Date: 2022-02-04

3 in total