Application of sodium alginate extracted from a Tunisian brown algae Padina pavonica for essential oil encapsulation: Microspheres preparation, characterization and in vitro release study.

In recent years, there has been considerable interest in essential oils encapsulation and in developing biodegradable microparticles. The aim of this present work was to prepare clove essential oil loaded microspheres, by a modified emulsification method, using sodium alginate extracted from a Tunisian Brown seaweed Algae Padina pavonica as biopolymer. The obtained microparticles were characterized by FT-IR, DSC and SEM. Loading capacity yield, encapsulation efficiency (%EE) and in vitro release of the essential oil were also investigated. Sodium alginate microspheres were successfully prepared as confirmed by physico-chemical characterizations. %yield of microspheres and %EE of essential oil were 72.73% and 24.77% ± 7.47%, respectively. SEM showed pseudospherical microspheres with rough surface ranging, in size, from 1500 μm to 3000 μm. In vitro dissolution study indicates a controlled released of the essential oil which follows, mainly, classical Fickian diffusion. Thus, this present work highlighted the potential of this polysaccharide as a biopolymer to formulate polymeric microspheres.