Fumihiro Kubota1, Tetsuyuki Suetsugu2, Aki Kato1, Fumi Gomi3, Seiji Takagi4, Takamasa Kinoshita5, Hiroto Ishikawa6, Yoshinori Mitamura7, Mineo Kondo8, Chiharu Iwahashi9, Soichiro Kuwayama1, Yasuo Kurimoto10, Yuichiro Ogura1, Tsutomu Yasukawa11. 1. Nagoya City University, Nagoya, Aichi, Japan. 2. Nagoya City University, Nagoya, Aichi, Japan; Dai Nagoya Building Eye Clinic, Nagoya, Aichi, Japan. 3. Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Sumitomo Hospital, Osaka, Osaka, Japan. 4. Kobe City Eye Hospital, Kobe, Hyogo, Japan; Teikyo University Mizonokuchi Hospital, Kawasaki, Kanagawa, Japan. 5. Sapporo City General Hospital, Sapporo, Hokkaido, Japan. 6. Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. 7. Tokushima University, Tokushima, Tokushima, Japan. 8. Mie University, Tsu, Mie, Japan. 9. Sumitomo Hospital, Osaka, Osaka, Japan. 10. Kobe City Eye Hospital, Kobe, Hyogo, Japan. 11. Nagoya City University, Nagoya, Aichi, Japan. Electronic address: yasukawa@med.nagoya-cu.ac.jp.
Abstract
PURPOSE: This study evaluated the long-term visual prognosis of a serous retinal detachment (SRD) secondary to tilted disc syndrome with or without an SRD at the final visit and the interventions. DESIGN: A retrospective, observational case series. METHODS: This was a multicenter study with an enrollment of 48 eyes of 41 treatment-naïve patients (14 men, 27 women) in whom tilted disc syndrome-related SRD was diagnosed at the first visit. Investigators at each institution decided whether to observe the patients without interventions or to treat with intravitreous injections of antivascular endothelial growth factor agents, photodynamic therapy, or both therapies combined. The patients were followed for at least 12 months. Main outcome measurements were changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) from baseline. RESULTS: Analyses of all eyes showed improvement from baseline when BCVA was measured (P < 0.0001), although last BCVA was similar to BCVA at baseline (P = 0.46). CRT significantly improved from that at baseline at the final visit (P < 0.0001). When eyes with or without SRD at the final visit were analyzed, baseline BCVAs (P = 0.22) were similar, whereas BCVA (P = 0.05) and last BCVA (P = 0.005) were significantly better in eyes without SRD. When eyes with or without the interventions were analyzed, baseline (P = 0.70), best (P = 0.99), and last (P = 0.70) BCVAs were similar. Last CRT significantly decreased from baseline CRT in eyes that had undergone interventions (P < 0.0001). CONCLUSIONS: The visual prognosis of SRD secondary to tilted disc syndrome was better when SRD resolved but was not influenced by the treatments.
PURPOSE: This study evaluated the long-term visual prognosis of a serous retinal detachment (SRD) secondary to tilted disc syndrome with or without an SRD at the final visit and the interventions. DESIGN: A retrospective, observational case series. METHODS: This was a multicenter study with an enrollment of 48 eyes of 41 treatment-naïve patients (14 men, 27 women) in whom tilted disc syndrome-related SRD was diagnosed at the first visit. Investigators at each institution decided whether to observe the patients without interventions or to treat with intravitreous injections of antivascular endothelial growth factor agents, photodynamic therapy, or both therapies combined. The patients were followed for at least 12 months. Main outcome measurements were changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) from baseline. RESULTS: Analyses of all eyes showed improvement from baseline when BCVA was measured (P < 0.0001), although last BCVA was similar to BCVA at baseline (P = 0.46). CRT significantly improved from that at baseline at the final visit (P < 0.0001). When eyes with or without SRD at the final visit were analyzed, baseline BCVAs (P = 0.22) were similar, whereas BCVA (P = 0.05) and last BCVA (P = 0.005) were significantly better in eyes without SRD. When eyes with or without the interventions were analyzed, baseline (P = 0.70), best (P = 0.99), and last (P = 0.70) BCVAs were similar. Last CRT significantly decreased from baseline CRT in eyes that had undergone interventions (P < 0.0001). CONCLUSIONS: The visual prognosis of SRD secondary to tilted disc syndrome was better when SRD resolved but was not influenced by the treatments.