BACKGROUND: Psychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates to objective functional outcomes in multiple sclerosis (MS). OBJECTIVE: To determine whether psychological resilience explains differential objective cognitive and motor functioning in persons with early MS. METHODS: Psychological resilience was assessed in 185 patients with early MS and 50 matched healthy controls with the Connors-Davidson Resilience Scale (CDRS-10). Subjects completed the MS Functional Composite (MSFC) and a comprehensive neurobehavioral evaluation. Correlations assessed links between CDRS-10 and MSFC, motor indices (Total, Fine Motor, Gross Motor), and cognitive indices (Total, Cognitive Efficiency, Memory). RESULTS: Higher CDRS-10 among patients was linked to better MSFC and motor outcomes (but not cognition), with the most robust relationships for gross motor function (grip strength, gait endurance). Findings were independent of mood and fatigue. CDRS-10 was unrelated to MS disease burden. CDRS-10 was also specifically linked to motor outcomes in healthy controls. CONCLUSION: Functional outcomes vary across persons with MS, even when disease burden and neurologic disability are low. These findings identify high psychological resilience as a non-disease-specific contributor to motor strength and endurance, which may explain differential outcomes across patients.
BACKGROUND: Psychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates to objective functional outcomes in multiple sclerosis (MS). OBJECTIVE: To determine whether psychological resilience explains differential objective cognitive and motor functioning in persons with early MS. METHODS: Psychological resilience was assessed in 185 patients with early MS and 50 matched healthy controls with the Connors-Davidson Resilience Scale (CDRS-10). Subjects completed the MS Functional Composite (MSFC) and a comprehensive neurobehavioral evaluation. Correlations assessed links between CDRS-10 and MSFC, motor indices (Total, Fine Motor, Gross Motor), and cognitive indices (Total, Cognitive Efficiency, Memory). RESULTS: Higher CDRS-10 among patients was linked to better MSFC and motor outcomes (but not cognition), with the most robust relationships for gross motor function (grip strength, gait endurance). Findings were independent of mood and fatigue. CDRS-10 was unrelated to MS disease burden. CDRS-10 was also specifically linked to motor outcomes in healthy controls. CONCLUSION: Functional outcomes vary across persons with MS, even when disease burden and neurologic disability are low. These findings identify high psychological resilience as a non-disease-specific contributor to motor strength and endurance, which may explain differential outcomes across patients.
Entities:
Keywords:
Multiple sclerosis; cognitive performance; motor function; psychological resilience
Authors: James F Sumowski; Maria A Rocca; Victoria M Leavitt; Alessandro Meani; Sarlota Mesaros; Jelena Drulovic; Paolo Preziosa; Christian G Habeck; Massimo Filippi Journal: Neurology Date: 2016-04-27 Impact factor: 9.910
Authors: Sandra Weintraub; Sureyya S Dikmen; Robert K Heaton; David S Tulsky; Philip D Zelazo; Patricia J Bauer; Noelle E Carlozzi; Jerry Slotkin; David Blitz; Kathleen Wallner-Allen; Nathan A Fox; Jennifer L Beaumont; Dan Mungas; Cindy J Nowinski; Jennifer Richler; Joanne A Deocampo; Jacob E Anderson; Jennifer J Manly; Beth Borosh; Richard Havlik; Kevin Conway; Emmeline Edwards; Lisa Freund; Jonathan W King; Claudia Moy; Ellen Witt; Richard C Gershon Journal: Neurology Date: 2013-03-12 Impact factor: 9.910
Authors: Hongxing Zhang; Dipesh Chaudhury; Alexander R Nectow; Allyson K Friedman; Song Zhang; Barbara Juarez; He Liu; Madeline L Pfau; Hossein Aleyasin; Cheng Jiang; Marshall Crumiller; Erin S Calipari; Stacy M Ku; Carole Morel; Nikos Tzavaras; Sarah E Montgomery; Michelle He; Stephen R Salton; Scott J Russo; Eric J Nestler; Jeffrey M Friedman; Jun-Li Cao; Ming-Hu Han Journal: Biol Psychiatry Date: 2018-09-06 Impact factor: 13.382
Authors: Bruce A C Cree; Pierre-Antoine Gourraud; Jorge R Oksenberg; Carolyn Bevan; Elizabeth Crabtree-Hartman; Jeffrey M Gelfand; Douglas S Goodin; Jennifer Graves; Ari J Green; Ellen Mowry; Darin T Okuda; Daniel Pelletier; H-Christian von Büdingen; Scott S Zamvil; Alisha Agrawal; Stacy Caillier; Caroline Ciocca; Refujia Gomez; Rachel Kanner; Robin Lincoln; Antoine Lizee; Pamela Qualley; Adam Santaniello; Leena Suleiman; Monica Bucci; Valentina Panara; Nico Papinutto; William A Stern; Alyssa H Zhu; Gary R Cutter; Sergio Baranzini; Roland G Henry; Stephen L Hauser Journal: Ann Neurol Date: 2016-08-13 Impact factor: 10.422
Authors: James F Sumowski; Sam Horng; Rachel Brandstadter; Stephen Krieger; Victoria M Leavitt; Ilana Katz Sand; Michelle Fabian; Sylvia Klineova; Robin Graney; Claire S Riley; Fred D Lublin; Aaron E Miller; Andrew W Varga Journal: Ann Clin Transl Neurol Date: 2021-05-05 Impact factor: 4.511