Kate Shearston1, Behrooz Fateh1, Shixiong Tai1, Dzikamai Hove1, Camile S Farah1,2. 1. UWA Dental School, University of Western Australia, Nedlands, Western Australia, Australia. 2. Australian Centre for Oral Oncology Research & Education, Nedlands, Western Australia, Australia.
Abstract
OBJECTIVES: Oral potentially malignant disorders (OPMD) include a variety of mucosal lesions such as oral lichen planus (OLP), oral lichenoid lesions (OLL) and oral lichenoid dysplasia (OLD). Their rate of malignant transformation ranges from 0% to 34% and is dependent on OPMD type, lesion site and a range of risk factors. This study seeks to determine the proportion of oral lichenoid conditions that transform into oral squamous cell carcinoma (OSCC) in an Australian population. METHODS: The study is a retrospective audit of patients from a private oral medicine clinic, diagnosed with OLP, OLL or OLD using clinical and histopathological data between 2006 and 2014. Patients were cross-matched with Cancer Registry data for OSCC, and the rate and time to malignant transformation determined. RESULTS: OLP and OLL patients displayed a low risk of malignant transformation; 0.49% (1/206) for OLP and 0% (0/31) for OLL. In contrast, OLD patients, all of whom presented clinically as OLP, were at much higher risk with 6.81% (3/44) developing OSCC over an average time of 4.6 years (±2.4 SD). Rates of smoking and alcohol consumption were no higher in OLD patients compared to others. CONCLUSIONS: Compared with other oral lichenoid conditions, OLD lesions are at a particularly high risk of malignant transformation and should be managed based on the presence of dysplasia and not the lichenoid inflammatory infiltrate. OLP demonstrates a relatively low rate of malignant transformation. Diagnostic histopathology is important for discriminating OLP from OLD.
OBJECTIVES: Oral potentially malignant disorders (OPMD) include a variety of mucosal lesions such as oral lichen planus (OLP), oral lichenoid lesions (OLL) and oral lichenoid dysplasia (OLD). Their rate of malignant transformation ranges from 0% to 34% and is dependent on OPMD type, lesion site and a range of risk factors. This study seeks to determine the proportion of oral lichenoid conditions that transform into oral squamous cell carcinoma (OSCC) in an Australian population. METHODS: The study is a retrospective audit of patients from a private oral medicine clinic, diagnosed with OLP, OLL or OLD using clinical and histopathological data between 2006 and 2014. Patients were cross-matched with Cancer Registry data for OSCC, and the rate and time to malignant transformation determined. RESULTS: OLP and OLL patients displayed a low risk of malignant transformation; 0.49% (1/206) for OLP and 0% (0/31) for OLL. In contrast, OLD patients, all of whom presented clinically as OLP, were at much higher risk with 6.81% (3/44) developing OSCC over an average time of 4.6 years (±2.4 SD). Rates of smoking and alcohol consumption were no higher in OLD patients compared to others. CONCLUSIONS: Compared with other oral lichenoid conditions, OLD lesions are at a particularly high risk of malignant transformation and should be managed based on the presence of dysplasia and not the lichenoid inflammatory infiltrate. OLP demonstrates a relatively low rate of malignant transformation. Diagnostic histopathology is important for discriminating OLP from OLD.
Authors: Letícia Côgo Marques; Laiza Angela de Medeiros Nunes da Silva; Pâmella de Pinho Montovani Santos; Amanda de Almeida Lima Borba Lopes; Karin Soares Cunha; Adrianna Milagres; Rafaela Elvira Rozza-de-Menezes; Arley Silva Junior; Danielle Castex Conde Journal: Head Face Med Date: 2022-09-06 Impact factor: 2.246
Authors: Vladimíra Radochová; Romana Koberová Ivančaková; Ondřej Heneberk; Radovan Slezák Journal: Int J Environ Res Public Health Date: 2021-06-17 Impact factor: 3.390
Authors: A Thirumal Raj; Shyam S Behura; Sachin C Sarode; Gargi S Sarode; Kamran Habib Awan; Shankargouda Patil Journal: Transl Cancer Res Date: 2020-04 Impact factor: 1.241