Sara Hallström1,2, Aldina Pivodic3,4, Annika Rosengren2, Arndís F Ólafsdóttir2,5, Ann-Marie Svensson2,6, Marcus Lind2,5. 1. Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden sara.el.nilsson@vgregion.se. 2. Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. 3. Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 4. Statistiska Konsultgruppen, Gothenburg, Sweden. 5. Department of Medicine, NU-Hospital Group, Uddevalla, Sweden. 6. Center of Registers in Region Västra Götaland, Gothenburg, Sweden.
Abstract
OBJECTIVE: This study identified variables associated with increased risk of atrial fibrillation in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: We performed a cohort study of people with type 1 diabetes from the Swedish National Diabetes Registry followed up between 1 January 2001 and 31 December 2013. Median follow-up was 9.7 years (interquartile range 5.2-13.0). The association between potential risk factors and incident atrial fibrillation was investigated using adjusted Cox regression. To compare the impact of each risk factor, the gradient of risk per 1 SD was estimated. RESULTS: In this cohort of 36,258 patients with type 1 diabetes, 749 developed atrial fibrillation during follow-up. Older age, male sex, renal complications, increased BMI and HbA1c, coronary artery disease, heart failure, and heart valve disease increased the risk of atrial fibrillation. Age, signs of renal dysfunction with macroalbuminuria, and decreasing estimated glomerular filtration rate were associated with the highest gradient of risk for atrial fibrillation. High blood pressure, severe obesity (BMI >35 kg/m2), and elevated levels of HbA1c (>9.6%) were associated with increased risk, but no associations were found with hyperlipidemia or smoking. CONCLUSIONS: The most prominent risk factors for atrial fibrillation in people with type 1 diabetes were older age, cardiovascular comorbidities, and renal complications, while obesity, hypertension, and hyperglycemia had more modest affects.
OBJECTIVE: This study identified variables associated with increased risk of atrial fibrillation in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: We performed a cohort study of people with type 1 diabetes from the Swedish National Diabetes Registry followed up between 1 January 2001 and 31 December 2013. Median follow-up was 9.7 years (interquartile range 5.2-13.0). The association between potential risk factors and incident atrial fibrillation was investigated using adjusted Cox regression. To compare the impact of each risk factor, the gradient of risk per 1 SD was estimated. RESULTS: In this cohort of 36,258 patients with type 1 diabetes, 749 developed atrial fibrillation during follow-up. Older age, male sex, renal complications, increased BMI and HbA1c, coronary artery disease, heart failure, and heart valve disease increased the risk of atrial fibrillation. Age, signs of renal dysfunction with macroalbuminuria, and decreasing estimated glomerular filtration rate were associated with the highest gradient of risk for atrial fibrillation. High blood pressure, severe obesity (BMI >35 kg/m2), and elevated levels of HbA1c (>9.6%) were associated with increased risk, but no associations were found with hyperlipidemia or smoking. CONCLUSIONS: The most prominent risk factors for atrial fibrillation in people with type 1 diabetes were older age, cardiovascular comorbidities, and renal complications, while obesity, hypertension, and hyperglycemia had more modest affects.
Authors: Sara Hallström; Ann-Marie Svensson; Aldina Pivodic; Arndís F Ólafsdóttir; Magnus Löndahl; Hans Wedel; Marcus Lind Journal: Diabetologia Date: 2021-09-08 Impact factor: 10.122
Authors: Muhammed Savran; Mesut Engin; Orhan Guvenc; Hasan F Yüksek; Sadık Ahmet Sünbül; Tamer Turk; Yusuf Ata; Ufuk Aydın; Ahmet F Ozyazicioglu Journal: J Saudi Heart Assoc Date: 2021-02-10