Literature DB >> 31171378

Positive margins after partial nephrectomy in renal cell carcinoma: Oncological outcomes of conservative management after long-term follow-up.

J J Fernández-Concha Schwalb1, J I Pérez Reggeti2, M A López Costea2, X Bonet Puntí2, H Ramos Reina2, F Vigués Julia2.   

Abstract

INTRODUCTION: Partial nephrectomy (PN) is the standard treatment for small and localized kidney tumours (cT1). One of the controversial aspects regarding this technique is the management of affected/positive resection margins. We present the long-term oncological results in patients with PSM after PN managed conservatively.
MATERIAL AND METHODS: There were 207 PN performed in our centre between 1990 and 2011. 17 patients presented PSM. 2 patients were excluded from the study due to completion nephrectomy afterwards. Follow-up was was done with abdominal contrast-enhanced computed tomography every 6 months for the first 2 years and subsequently, once a year. Cancer-specific survival and disease-free survival were calculated with the Kaplan-Meier method.
RESULTS: The median age was 62 years (RIQ: 55-71) and the mean tumour size was 34.8 (10-77) mm. Histopathological results were: 6 (40%) clear cell RCC, 4 (26.7%) papillary, 3 (20%) chromophobe and 2 (13.3%) oncocytic. The pathologic stages were: 11 (73.3%) pT1a, 1 (6.7%) pT1b and 3 (20%) pT3a. The median follow-up was 84 months (IQR 72-120). 2 patients had metastatic recurrence and this was the cause of death. The first one had recurrence at 112 months and the second one at 59. 5-year CSS and RFS were 87.5% and 93.3% respectively.
CONCLUSIONS: In our experience, patients with PSM after PN can be managed conservatively with satisfactory long-term oncological outcomes.
Copyright © 2019 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

Entities:  

Keywords:  Carcinoma renal; Márgenes positivos; Nefrectomía parcial; Partial nephrectomy; Positive margins; Renal cell carcinoma

Mesh:

Year:  2019        PMID: 31171378     DOI: 10.1016/j.acuro.2019.03.002

Source DB:  PubMed          Journal:  Actas Urol Esp (Engl Ed)        ISSN: 2173-5786


  1 in total

Review 1.  Current strategies to diagnose and manage positive surgical margins and local recurrence after partial nephrectomy.

Authors:  Umberto Carbonara; Daniele Amparore; Cosimo Gentile; Riccardo Bertolo; Selcuk Erdem; Alexandre Ingels; Michele Marchioni; Constantijn H J Muselaers; Onder Kara; Laura Marandino; Nicola Pavan; Eduard Roussel; Angela Pecoraro; Fabio Crocerossa; Giuseppe Torre; Riccardo Campi; Pasquale Ditonno
Journal:  Asian J Urol       Date:  2022-06-14
  1 in total

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