Literature DB >> 31170842

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics.

Christina L Burnett1, Ivan Boyer2, Wilma F Bergfeld3, Donald V Belsito3, Ronald A Hill3, Curtis D Klaassen3, Daniel C Liebler3, James G Marks3, Ronald C Shank3, Thomas J Slaga3, Paul W Snyder3, Lillian J Gill4, Bart Heldreth5.   

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.

Entities:  

Keywords:  cosmetics; methylisothiazolinone; safety

Year:  2019        PMID： 31170842     DOI： 10.1177/1091581819838792

Source DB:  PubMed          Journal:  Int J Toxicol        ISSN： 1091-5818            Impact factor:   2.032


  2 in total

1.  A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species.

Authors:  Van Quan Do; Yoon-Seok Seo; Jung-Min Park; Jieun Yu; Men Thi Hoai Duong; Junichi Nakai; Sang-Kyum Kim; Hee-Chul Ahn; Moo-Yeol Lee
Journal:  Arch Toxicol       Date:  2020-10-19       Impact factor: 5.153

Review 2.  The science behind wet wipes for infant skin: Ingredient review, safety, and efficacy.

Authors:  Karien J Rodriguez; Corey Cunningham; Robert Foxenberg; Douglas Hoffman; Rebecca Vongsa
Journal:  Pediatr Dermatol       Date:  2020-02-17       Impact factor: 1.588
  2 in total

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