Lingling Zhang1, Sida Shen2, Liang Cheng2, Hongjun You3, Lu Lu4, Chuansheng Ma4, Yanzhu Dai4, Jixiang Fang1. 1. School of Electronic & Information Engineering, Xi'an Jiaotong University, Xi'an, Shann xi 710049, PR China. 2. Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou, Jiangsu 215123, PR China. 3. School of Science, Xi'an Jiaotong University, Xi'an, Shann xi 710049, PR China. 4. School of Microelectronics, Xi'an Jiaotong University, Xi'an, Shann xi 710049, PR China.
Abstract
Aim: To realize the transit and release of cancer drug exactly as well as high drug loading ratio, we reported a biocompatible and temperature responsive controlled drug delivery system based on 3D mesoporous structured Au networks. Materials & methods: Here, we filled the hollow interiors of Au networks with a phase-change material so that the drug release was easily regulated by controlling the temperature only. Results: Thanks to the high near-infrared reflectance absorbance and mesoporous structure, the Au-PEG + lauric acid/doxorubicin system showed a strong photothermal conversion efficiency, high drug-loading ratio (54.2% for doxorubicin) and controlled drug release. Conclusion: This system revealed great advantages in photothermal therapy and chemotherapy, offering an obvious synergistic effect in cancer treatment.
Aim: To realize the transit and release of cancer drug exactly as well as high drug loading ratio, we reported a biocompatible and temperature responsive controlled drug delivery system based on 3D mesoporous structured Au networks. Materials & methods: Here, we filled the hollow interiors of Au networks with a phase-change material so that the drug release was easily regulated by controlling the temperature only. Results: Thanks to the high near-infrared reflectance absorbance and mesoporous structure, the Au-PEG + lauric acid/doxorubicin system showed a strong photothermal conversion efficiency, high drug-loading ratio (54.2% for doxorubicin) and controlled drug release. Conclusion: This system revealed great advantages in photothermal therapy and chemotherapy, offering an obvious synergistic effect in cancer treatment.
Entities:
Keywords:
Au networks; cancer treatment; drug control release; high drug-loading ratio; phase-change material