X Wang1, X Tian2, B Ye2, Y Zhang1, C Li3, J Liao4, Y Zou2,5, S Zhang1, Y Zhu2, J Yang1, L Ma2,5. 1. Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, China. 2. Department of Healthcare Management, School of Health Sciences, Wuhan University, Wuhan, China. 3. Centre for Diseases Control and Prevention of the Lianyungang Economic and Technological Development Area, Lianyungang, China. 4. Department of Public Health, Wuhan University of Science and Technology School of Medicine, Wuhan, China. 5. Global Health Institute, Wuhan University, Wuhan, China.
Abstract
BACKGROUND: Limited studies have explored the association between gaseous pollutant exposures and male reproductive outcomes, and findings remained inconsistent. OBJECTIVES: To evaluate the potential association between gaseous pollutants and semen quality within different exposure windows. MATERIALS AND METHODS: We adopted semen quality data of 1852 subjects who attended the Reproductive Medicine Center of Renmin Hospital at Wuhan University during January 1st, 2013, to August 3rd, 2015. A generalized linear model was employed to assess the relationship between each exposure variable and sperm parameters in different exposure windows. RESULTS: SO2 exposure with lag 0-90 days was significantly associated with decreased sperm concentration (β: -1.362; 95% CI: -1.844, -0.879), sperm count (β: -2.979; 95% CI: -4.267, -1.691), and PR (β: -0.551; 95% CI: -0.710, -0.393). Similar trends were observed for SO2 exposure with three other key periods (lag 0-9, 10-14, and 70-90 days). NO2 exposure with lag 0-90 days was also associated with decreased sperm concentration (β: -0.517; 95% CI: -1.006, -0.027), sperm count (β: -1.914; 95% CI: -3.214, -0.615), and PR (β: -0.264; 95% CI: -0.425, -0.102). No relationship between gaseous pollutant exposure and ejaculate volume was observed in any exposure window. DISCUSSION AND CONCLUSION: Our study indicated a strong adverse effect of gaseous pollutants on semen quality outcomes during the sperm development. Gaseous pollution exposure appeared to be more detrimental in the initial phase of spermatogenesis.
BACKGROUND: Limited studies have explored the association between gaseous pollutant exposures and male reproductive outcomes, and findings remained inconsistent. OBJECTIVES: To evaluate the potential association between gaseous pollutants and semen quality within different exposure windows. MATERIALS AND METHODS: We adopted semen quality data of 1852 subjects who attended the Reproductive Medicine Center of Renmin Hospital at Wuhan University during January 1st, 2013, to August 3rd, 2015. A generalized linear model was employed to assess the relationship between each exposure variable and sperm parameters in different exposure windows. RESULTS:SO2 exposure with lag 0-90 days was significantly associated with decreased sperm concentration (β: -1.362; 95% CI: -1.844, -0.879), sperm count (β: -2.979; 95% CI: -4.267, -1.691), and PR (β: -0.551; 95% CI: -0.710, -0.393). Similar trends were observed for SO2 exposure with three other key periods (lag 0-9, 10-14, and 70-90 days). NO2 exposure with lag 0-90 days was also associated with decreased sperm concentration (β: -0.517; 95% CI: -1.006, -0.027), sperm count (β: -1.914; 95% CI: -3.214, -0.615), and PR (β: -0.264; 95% CI: -0.425, -0.102). No relationship between gaseous pollutant exposure and ejaculate volume was observed in any exposure window. DISCUSSION AND CONCLUSION: Our study indicated a strong adverse effect of gaseous pollutants on semen quality outcomes during the sperm development. Gaseous pollution exposure appeared to be more detrimental in the initial phase of spermatogenesis.
Authors: Trenton D Henry; Christina A Porucznik; Trenton J Honda; James A VanDerslice; Brenna E Blackburn; Kyley J Cox; Douglas T Carrell Journal: Ecotoxicol Environ Saf Date: 2021-06-11 Impact factor: 7.129